Global Patent Index - EP 0986746 A1

EP 0986746 A1 2000-03-22 - ON-LINE LIQUID SAMPLE DEPOSITION INTERFACE FOR MATRIX ASSISTED LASER DESORPTION IONIZATION-TIME OF FLIGHT (MALDI-TOF) MASS SPECTROSCOPY

Title (en)

ON-LINE LIQUID SAMPLE DEPOSITION INTERFACE FOR MATRIX ASSISTED LASER DESORPTION IONIZATION-TIME OF FLIGHT (MALDI-TOF) MASS SPECTROSCOPY

Title (de)

SCHNITTSTELLE ZUM ON-LINE ABLEGEN VON FLÜSSIGE P*ROBEN FÜR MATRIXUNTERSTÜTZTER LASERIONISATIONS UND -DESORPTIONSFLUGZEITMASSENSPEKTROMETRIE

Title (fr)

INTERFACE DE DEPOT EN LIGNE D'ECHANTILLONS LIQUIDES POUR SPECTROSCOPIE DE MASSE A TEMPS DE VOL A IONISATION-DESORPTION LASER ASSISTEE PAR MATRICE (MALDI-TOF)

Publication

EP 0986746 A1 (EN)

Application

EP 98924853 A

Priority

  • US 9810537 W
  • US 4748997 P

Abstract (en)

[origin: WO9853308A1] An universal interface for continuous on-line liquid sample introduction directly into the source chamber (5) of a time-of-flight mass spectrometer (20) for matrix-assisted-laser-desorption-ionization (MALDI) analysis is disclosed. The liquid sample includes a liquid or solid matrix material used in conventional MALDI analysis and is deposited directly onto a moving sample holder (22) in the source chamber (5). The sample holder (22) is at subatmospheric pressure, causing the rapid drying of the sample. The dried sample is subsequently desorbed from the sample holder (22) by a nitrogen laser (28) in a desorption region (26). The method of the invention is particularly amenable to multiplexing, the parallel deposition of multiple samples from an array of capillaries or microchip channels (24), with the subsequent sequential desorption by a scanning laser. This format is particularly useful for high throughput mass spectrometric analysis.

IPC 1-7 (main, further and additional classification)

G01N 24/00; G01N 27/64; G01N 1/22; B01D 59/44; H01J 49/00

IPC 8 full level (invention and additional information)

G01N 27/62 (2006.01); G01N 1/00 (2006.01); G01N 27/64 (2006.01); H01J 49/04 (2006.01); G01N 1/22 (2006.01)

CPC (invention and additional information)

H01J 49/0418 (2013.01); H01J 49/0431 (2013.01)

Designated contracting state (EPC)

CH DE FR GB LI

EPO simple patent family

WO 9853308 A1 19981126; EP 0986746 A1 20000322; JP 2002502543 A 20020122

INPADOC legal status


2005-06-15 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041201

2000-03-22 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991210

2000-03-22 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): CH DE FR GB LI