Global patent index - EP 0988034 A1

EP 0988034 A1 2000-03-29 - COX-2 SELECTIVE CARPROFEN FOR TREATING PAIN AND INFLAMMATION IN DOGS

Title (en)

COX-2 SELECTIVE CARPROFEN FOR TREATING PAIN AND INFLAMMATION IN DOGS

Title (de)

COX-2 SELEKTIVES CARPROFEN ZUR BEHANDLUNG VON SCHMERZ UND ENTZUENDUNG BEI HUNDEN

Title (fr)

CARPROFENE INHIBANT SELECTIVEMENT COX-2 ET UTILISE DANS LE TRAITEMENT DE LA DOULEUR ET DES INFLAMMATIONS CHEZ LES CHIENS

Publication

EP 0988034 A1 (EN)

Application

EP 98915041 A

Priority

  • IB 9800662 W
  • US 4563597 P

Abstract (en)

[origin: WO9850033A1] Treating or preventing inflammatory processes and diseases in dogs associated with the activity of inducible cyclo-oxygenase-2 (COX-2), while at the same time reducing or eliminating undesirable side effects associated with simultaneous inhibition of the activity of constitutive cyclo-oxygenase-1 (COX-1) by selectively inhibiting COX-2 activity with reference to COX-1 activity, wherein the selectivity ratio or COX-2 : COX-1 activity inhibition is at least 3 : 1 based on ex vivo inhibition levels measured in whole blood; the inhibitor is a member selected from the group of anti-inflammatory compounds consisting essentially of salicylic acid derivatives, p-aminophenol derivatives, indole and indene acetic acids, heteroaryl acetic acids, arylpropionic acids, anthranilic acids, enolic acids, and alkanones; the inhibitor in particular is comprised of (+)(S)-enantiomer of 6-chloro- alpha -methyl-9H-carbazole-2-acetic acid.

IPC 1-7 (main, further and additional classification)

A61K 31/40

IPC 8 full level (invention and additional information)

A61K 31/403 (2006.01); A61K 31/40 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 209/88 (2006.01)

CPC (invention and additional information)

A61K 31/40 (2013.01)

Citation (search report)

See references of WO 9850033A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9850033 A1 19981112; AP 9801234 D0 19980630; AR 011726 A1 20000830; AR 039628 A2 20050302; AU 6932198 A 19981127; BG 103852 A 20000630; BR 9808720 A 20000711; CA 2288759 A1 19981112; CN 1255059 A 20000531; DZ 2479 A1 20030201; EA 003696 B1 20030828; EP 0988034 A1 20000329; GT 199800063 A 19991026; HR P980244 A2 19990228; HU 0001286 A2 20001128; HU 0001286 A3 20001228; ID 21311 A 19990520; IL 132570 D0 20010319; IS 5220 A 19991019; JP 2000513020 A 20001003; KR 20010012300 A 20010215; KR 20040004406 A 20040113; MA 26491 A1 20041220; NO 995389 A 20000104; NO 995389 D0 19991104; NZ 500183 A 20020426; OA 11213 A 20030714; PA 8450601 A1 20000524; PE 72599 A1 19990812; PL 337003 A1 20000731; SK 148199 A3 20010911; TN SN98059 A1 20000613; TW 590773 B 20040611; UY 24989 A1 20011025; YU 55899 A 20030829; ZA 9803722 B 19991104

INPADOC legal status

2004-10-13 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040414

2002-04-17 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020305

2000-03-29 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991105

2000-03-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-03-29 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 19991105;LT PAYMENT 19991105;LV PAYMENT 19991105;MK PAYMENT 19991105;RO PAYMENT 19991105;SI PAYMENT 19991105