Global patent index - EP 0988280 A1

EP 0988280 A1 2000-03-29 - HYDROXAMIC ACID COMPOUNDS HAVING ANTICANCER AND ANTI-PARASITIC PROPERTIES

Title (en)

HYDROXAMIC ACID COMPOUNDS HAVING ANTICANCER AND ANTI-PARASITIC PROPERTIES

Title (de)

HYDROXAMSÄUREVERBINDUNGEN DIE SICH ALS ANTIKREBS- UND ALS ANTIPARASITÄRE MITTEL EIGNEN

Title (fr)

COMPOSES D'ACIDE HYDROXAMIQUE AYANT DES PROPRIETES ANTICANCEREUSES ET ANTIPARASITAIRES

Publication

EP 0988280 A1 (EN)

Application

EP 98925331 A

Priority

  • AU 9800431 W
  • AU PO721997 A

Abstract (en)

[origin: WO9855449A1] The invention provides a hydroxamate or hydroxamic acid compound of general formula (Ia) or (Ib): HONH-[linker]-X<1>R<1>R<2> or (Ic): R<1>R<2>X<1>-[linker]-X<1>R<1>R<2>, in which X<1> is a polar group selected from the group consisting of -C=O; -COR<1>; -CF2; -CNH2; -CNR<1>; -SO2-; -P(O)(OH)-; -C=S; -CSR<1>; -C-COR<1>; -C-CONR<1>R<2> and -C-CH2OH; R<1> and R<2> are the same or different, and each is independently selected from the group consisting of H; OH; NH2; NHOH; substituted or unsubstituted, branched or unbranched alkyl, alkenyl, alkylamino, alkyloxy or arylalkyloxy; substituted or unsubstituted aryl, aryloxy or pyridino; substituted or unsubstituted arylamino, piperidino, cycloalkyl, cycloalkylamino, pyridineamino, 9-purine-6-amine, and thiazoleamino; or either R<1> or R<2> is absent; and the linker is a group having a backbone of 5 to 9 atoms, which may comprise 1, 2 or 3 amino acids, or a pharmaceutically acceptable salt, ester or derivative thereof. The compounds have the ability to selectively prevent the growth of a variety of human tumour cell types, without affecting growth of normal cells. The compounds of the invention also inhibit the growth of protozoan parasites.

IPC 1-7 (main, further and additional classification)

C07C 259/04; A61K 31/16; A61K 31/165; A61K 31/38; A61K 38/05; A61K 38/06; A61K 38/12; C07C 259/06; C07C 259/08; C07C 259/10; C07D 209/44; C07D 209/48; C07D 217/14; C07D 217/16; C07D 217/22; C07D 217/24; C07K 5/04

IPC 8 full level (invention and additional information)

C07D 333/34 (2006.01); A61K 31/16 (2006.01); A61K 31/352 (2006.01); A61K 31/381 (2006.01); A61K 31/382 (2006.01); A61K 31/4035 (2006.01); A61K 31/47 (2006.01); A61K 31/472 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 17/06 (2006.01); A61P 17/16 (2006.01); A61P 31/04 (2006.01); A61P 33/02 (2006.01); A61P 35/00 (2006.01); C07C 259/06 (2006.01); C07C 259/10 (2006.01); C07C 275/44 (2006.01); C07D 215/02 (2006.01); C07D 217/24 (2006.01); C07D 311/22 (2006.01); C07D 311/58 (2006.01); C07D 335/06 (2006.01); C07K 5/065 (2006.01); C07K 5/08 (2006.01); C40B 40/02 (2006.01); C40B 40/04 (2006.01); C40B 50/06 (2006.01)

CPC (invention and additional information)

A61K 31/16 (2013.01); A61K 31/381 (2013.01); A61K 31/4035 (2013.01); C07C 259/06 (2013.01); C07K 5/06078 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9855449A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9855449 A1 19981210; AU PO721997 D0 19970703; EP 0988280 A1 20000329; JP 2002513419 A 20020508

INPADOC legal status

2007-01-12 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Ref Legal Event Code: WD

- Ref Document Number: 1026887

- Country of Ref Document: HK

2003-03-19 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20030123

2001-05-16 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: THE UNIVERSITY OF QUEENSLAND

- Ref Legal Event Code: RAP1

2000-03-29 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991223

2000-03-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE