Global Patent Index - EP 0988282 A2

EP 0988282 A2 2000-03-29 - NOVEL PENTAERYTHRITE DERIVATIVES, THE PRODUCTION AND USE THEREOF AND INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF THE SAME

Title (en)

NOVEL PENTAERYTHRITE DERIVATIVES, THE PRODUCTION AND USE THEREOF AND INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF THE SAME

Title (de)

NEUE PENTAERYTHRITDERIVATE, DEREN HERSTELLUNG UND VERWENDUNG SOWIE INTERMEDIATE ZUR SYNTHESE DERSELBEN

Title (fr)

NOUVEAUX DERIVES DE PENTAERYTHRITE, LEUR PRODUCTION, LEUR UTILISATION ET INTERMEDIAIRES POUR LEUR SYNTHESE

Publication

EP 0988282 A2 (DE)

Application

EP 98936180 A

Priority

  • DE 9801635 W
  • DE 19725340 A

Abstract (en)

[origin: DE19826781A1] Pentaerythritol derivatives of formula (I), (III), (VI), (VII), (VIII) and (XV) and their salts are new: (O2NOCH2)mC(CH2OH)n(CH2COR<1>)o(COR<1>)p (I) (O2NOCH2)mC(CH2OH)n(CH2COR<3>)o(COR<3>)p (III) (O2NOCH2)mC(CH2OH)n(CH2COR<5>)o(COR<5>)p (VI) (HOCH2)q(O2NOCH2)rC(CH2OR<6>)s (VII) (O2NOCH2)mC(CH2OH)n(CH2COR<7>)o(COR<7>)p (VIII) (HOCH2)q(O2NOCH2)rC(CH2OR<14>)s (XV) R<1> = a group of formula (II); R<3> = a group of formula (IV); R<5> = (2-carboxyphenyl)oxy or (2-alkoxycarbonylphenyl)oxy; R<6> = salicyloyl or acetylsalicyloyl; R<7> = a group of formula (IX); R<14> = acyl radical of a compound of formula (X), (XI), (XII), (XIII) or (XIV) (sic); R<2> = 1-20C alkyl, especially Me, Et, n-Pr, i-Pr, n-butyl, n-pentyl, n-hexyl, n-octyl, benzyl, cyclohexylmethyl, 4-chlorobenzyl, 4-nitrobenzyl, 2-phenylethyl, 3-phenylpropyl, 3-cyclohexylpropyl, 3-phthalimidylpropyl, 1-naphthylmethyl, cinnamyl, 5-ethoxycarbonylbutyl, 3-aminopropyl, -(CH2)3CH(NHCOCH3)COOH, -(CH2)3CH(NHCOCH3)COOCH3 or 1,6-hexane-bis; R<8>, R<9> = 1-6C alkyl or R<8>+R<9> = 1-6C alkylene; R<10> = OH, NHR<8>R<9>, 1-6C alkoxy, (2-carboxyphenyl)oxy, (2-alkoxycarbonylphenyl)oxy, (1-carboxymethyl-2-dialkylamino)ethoxy, (1-carboxymethyl-2-trialkylammonium)ethoxy, (1-alkoxycarbonylmethyl-2-dialkylamino)ethoxy or (1-alkoxycarbonylmethyl-2-trialkylammonium)ethoxy; m, p, r, s \-1; m+n+o+p = 4; q+r+s = 4. Also claimed are compounds of formula (V), (X), (XI) and (XIV) and their salts. R<4> = H, 1-6C alkanoyl, salicyloyl or acetylsalicyloyl; R<11> = NO2 and for (XV) H, 1-6C alkanoyl, salicyloyl, acetylsalicyloyl or -CO-CH2CH(OH)-CH2-NR<8>R<9>; R<12> = 1-6C alkyl, especially Me, Et or n-Pr; R<13> = H or 1-6C alkyl; X = an anion or absent if COR<10> is capable of forming an inner salt.

IPC 1-7 (main, further and additional classification)

C07C 271/00

IPC 8 full level (invention and additional information)

C07D 271/06 (2006.01); A61K 31/216 (2006.01); A61K 31/221 (2006.01); A61K 31/4245 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 43/00 (2006.01); C07C 229/22 (2006.01); C07D 271/113 (2006.01); C07D 271/10 (2006.01)

CPC (invention and additional information)

C07D 271/113 (2013.01); C07C 229/22 (2013.01)

Citation (search report)

See references of WO 9856759A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19826781 A1 19981217; AU 8532198 A 19981230; BG 104021 A 20000731; CA 2293407 A1 19981217; CN 1266429 A 20000913; DE 19880813 D2 20000531; EA 200000006 A1 20000828; EE 9900568 A 20000815; EP 0988282 A2 20000329; HR P980313 A2 19990430; HU 0002925 A2 20010730; HU 0002925 A3 20021128; IL 133410 D0 20010430; JP 2002504903 A 20020212; NO 996128 A 19991210; NO 996128 D0 19991210; NZ 501414 A 20011221; PL 337775 A1 20000911; SK 169599 A3 20001107; TR 200003352 T2 20010221; TR 9903054 T2 20000721; US 6365611 B1 20020402; WO 9856759 A2 19981217; WO 9856759 A3 19990916; ZA 9805064 B 19980828

INPADOC legal status


2002-05-15 [18W] WITHDRAWN

- Date of withdrawal: 20020321

2001-08-22 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010709

2000-03-29 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991208

2000-03-29 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-03-29 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19991208;LT PAYMENT 19991208;LV PAYMENT 19991208;MK PAYMENT 19991208;RO PAYMENT 19991208;SI PAYMENT 19991208