EP 0988295 A4 20030813 - HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF

Title (en)

HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF

Title (de)

DURCH EINEN HETEROZYKLISCHEN REST SUBSTITUIERTE PIPERIDINE UND IHRE ANWENDUNG

Title (fr)

PIPERIDINES A SUBSTITUTION HETEROCYCLIQUE ET UTILISATIONS DE CES DERNIERES

Publication

EP 0988295 A4 20030813 (EN)

Application

EP 98931350 A 19980617

Priority

US 9812668 W 19980617
US 87784697 A 19970618

Abstract (en)

[origin: WO9857940A1] This invention is directed to oxazolidinone compounds which are selective antagonists for human alpha 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the alpha 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

IPC 1-7

C07D 263/20; C07D 277/14; C07D 403/06; C07D 411/12; C07D 413/12; A61K 31/415; A61K 31/42; A61K 31/425; A61K 31/445; A61K 31/495; C07D 263/26; C07D 265/10; C07D 401/12; C07D 401/14; C07D 413/14; C07D 417/14

IPC 8 full level

C07D 263/22 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/5355 (2006.01); A61P 3/06 (2006.01); A61P 9/06 (2006.01); A61P 13/08 (2006.01); A61P 15/10 (2006.01); A61P 27/06 (2006.01); A61P 43/00 (2006.01); C07D 263/20 (2006.01); C07D 263/26 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01)

CPC (source: EP)

A61P 3/06 (2017.12); A61P 9/06 (2017.12); A61P 13/08 (2017.12); A61P 15/10 (2017.12); A61P 27/06 (2017.12); A61P 43/00 (2017.12); C07D 263/20 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)

Citation (search report)

[A] WO 9614846 A1 19960523 - SYNAPTIC PHARMA CORP [US], et al
[A] WO 9717969 A1 19970522 - SYNAPTIC PHARMA CORP [US], et al
See references of WO 9857940A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9857940 A1 19981223; AU 740064 B2 20011025; AU 8149898 A 19990104; CA 2294549 A1 19981223; EP 0988295 A1 20000329; EP 0988295 A4 20030813; JP 2002505683 A 20020219

DOCDB simple family (application)

US 9812668 W 19980617; AU 8149898 A 19980617; CA 2294549 A 19980617; EP 98931350 A 19980617; JP 50477899 A 19980617