EP 0988321 A2 20000329 - B7-BINDING MOLECULES FOR TREATING IMMUNE DISEASES
Title (en)
B7-BINDING MOLECULES FOR TREATING IMMUNE DISEASES
Title (de)
B7-BINDUNGSMOLEKÜLEN ZUR BEHANDLUNG VON IMMUNKRANKHEITEN
Title (fr)
MOLECULES DE LIAISON AVEC B7 DESTINEES AU TRAITEMENT D'AFFECTIONS IMMUNITAIRES
Publication
Application
Priority
- EP 98939523 A 19980622
- EP 9803791 W 19980622
- EP 97870092 A 19970620
Abstract (en)
[origin: WO9858965A2] The present invention relates to molecules, such as diabodies, tri- and tetravalent antibodies and small antigen binding peptides, which can cross-link or cross-react with the costimulatory molecules B7.1 and B7.2 expressed on professional antigen presenting cells (APCs) leading to the inhibition of antigen-specific T cell activation. The present invention also concerns methods to produce these molecules and use of these molecules to treat diseases, such as transplant rejection, graft versus host disease (GVHD), allergy and autoimmune diseases, where antigen-specific T cell activation is pathogenic.
IPC 1-7
C07K 16/28; C07K 16/46; C07K 16/00; A61K 39/395; A61K 38/13; A61K 31/445; A61K 31/57
IPC 8 full level
A61K 31/445 (2006.01); A61K 31/57 (2006.01); A61K 38/13 (2006.01); A61K 39/395 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 39/395 (2013.01); C07K 14/70521 (2013.01); C07K 16/2827 (2013.01); A61K 38/00 (2013.01); C07K 2317/34 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9858965A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9858965 A2 19981230; WO 9858965 A3 19990514; AU 8800598 A 19990104; CA 2292415 A1 19981230; EP 0988321 A2 20000329
DOCDB simple family (application)
EP 9803791 W 19980622; AU 8800598 A 19980622; CA 2292415 A 19980622; EP 98939523 A 19980622