Global patent index - EP 0988321 A2

EP 0988321 A2 2000-03-29 - B7-BINDING MOLECULES FOR TREATING IMMUNE DISEASES

Title (en)

B7-BINDING MOLECULES FOR TREATING IMMUNE DISEASES

Title (de)

B7-BINDUNGSMOLEKÜLEN ZUR BEHANDLUNG VON IMMUNKRANKHEITEN

Title (fr)

MOLECULES DE LIAISON AVEC B7 DESTINEES AU TRAITEMENT D'AFFECTIONS IMMUNITAIRES

Publication

EP 0988321 A2 (EN)

Application

EP 98939523 A

Priority

  • EP 98939523 A
  • EP 9803791 W
  • EP 97870092 A

Abstract (en)

[origin: WO9858965A2] The present invention relates to molecules, such as diabodies, tri- and tetravalent antibodies and small antigen binding peptides, which can cross-link or cross-react with the costimulatory molecules B7.1 and B7.2 expressed on professional antigen presenting cells (APCs) leading to the inhibition of antigen-specific T cell activation. The present invention also concerns methods to produce these molecules and use of these molecules to treat diseases, such as transplant rejection, graft versus host disease (GVHD), allergy and autoimmune diseases, where antigen-specific T cell activation is pathogenic.

IPC 1-7 (main, further and additional classification)

C07K 16/28; A61K 31/445; A61K 31/57; A61K 38/13; A61K 39/395; C07K 16/00; C07K 16/46

IPC 8 full level (invention and additional information)

A61K 31/445 (2006.01); A61K 31/57 (2006.01); A61K 38/13 (2006.01); A61K 39/395 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 16/2827 (2013.01); A61K 39/395 (2013.01); C07K 14/70521 (2013.01); A61K 38/00 (2013.01); C07K 2317/34 (2013.01); C07K 2319/00 (2013.01)

Combination set (CPC)

  1. A61K 39/395 + A61K 38/00
  2. A61K 39/395 + A61K 31/00
  3. A61K 39/395 + A61K 2300/00

Citation (search report)

See references of WO 9858965A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9858965 A2 19981230; WO 9858965 A3 19990514; AU 8800598 A 19990104; CA 2292415 A1 19981230; EP 0988321 A2 20000329

INPADOC legal status

2003-07-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030102

2000-03-29 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000114

2000-03-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-03-29 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: LT PAYMENT 20000114;LV PAYMENT 20000114;RO PAYMENT 20000114;SI PAYMENT 20000114