Global Patent Index - EP 0989855 A1

EP 0989855 A1 2000-04-05 - OSTEOARTHRITIS CARTILAGE REGENERATION USING HUMAN MESENCHYMAL STEM CELLS

Title (en)

OSTEOARTHRITIS CARTILAGE REGENERATION USING HUMAN MESENCHYMAL STEM CELLS

Title (de)

REGENERATION VON KNORPEL BEI OSTEOARTHRITIS MITTELS MENSCHLICHER MESENCHYMALER STAMMZELLEN

Title (fr)

REGENERATION DE CARTILAGE DANS L'ARTHROSE A L'AIDE DE CELLULES SOUCHES MESENCHYMATEUSES HUMAINES

Publication

EP 0989855 A1 (EN)

Application

EP 98922211 A

Priority

  • US 9809614 W
  • US 4700297 P

Abstract (en)

[origin: WO9851317A1] For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: 1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); 2) broaden the suitable clinical population to routinely include middle-aged patients; 3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; 4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; 5) regenerate articular joint cartilage in older patients with osteoarthritis; and 6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.

IPC 1-7 (main, further and additional classification)

A61K 35/28; C12N 5/02; C12N 5/08

IPC 8 full level (invention and additional information)

A61L 27/38 (2006.01); C12N 5/02 (2006.01); C12N 5/077 (2010.01); C12N 5/0775 (2010.01); A61K 35/12 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

A61L 27/3886 (2013.01); A61L 27/3817 (2013.01); A61L 27/3834 (2013.01); A61L 27/3852 (2013.01); C12N 5/0655 (2013.01); C12N 5/0663 (2013.01); A61K 38/00 (2013.01); A61K 2035/124 (2013.01); A61L 2430/06 (2013.01); C12N 2500/38 (2013.01); C12N 2501/15 (2013.01); C12N 2501/23 (2013.01); C12N 2501/39 (2013.01); C12N 2501/70 (2013.01); C12N 2533/54 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9851317 A1 19981119; AU 7481098 A 19981208; CA 2288690 A1 19981119; EP 0989855 A1 20000405; EP 0989855 A4 20020612; EP 2110431 A1 20091021

INPADOC legal status


2009-09-16 [18R] REFUSED

- Effective date: 20090801

2003-09-24 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030811

2002-06-12 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020503

2002-06-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-06-12 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 12N 5/06 A, 7A 61K 38/39 B, 7A 61K 38/18 B, 7C 12N 5/06 J, 7A 61K 38:39 J, 7A 61K 38:18 J

2000-04-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991129

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE