EP 0989979 A1 20000405 - NOVEL N-SUBSTITUTED UREA INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Title (en)
NOVEL N-SUBSTITUTED UREA INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Title (de)
N-SUBSTITUIERTE HARNSTOFF DERIVATE ALS INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE
Title (fr)
NOUVEAUX COMPOSES D'UREE N-SUBSTITUES INHIBITEURS DE LA FARNESYL TRANSFERASE
Publication
Application
Priority
- US 9811507 W 19980615
- US 87704997 A 19970617
Abstract (en)
[origin: WO9857948A1] Novel halo-N-substituted urea compounds and pharmaceutical compositions of formula (1.0) or a pharmaceutically acceptable salt or solvate theroef, are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
IPC 1-7
IPC 8 full level
A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2018.01 - EP); C07D 401/04 (2013.01 - KR); C07D 401/12 (2013.01 - EP); C07D 401/14 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9857948 A1 19981223; AR 013094 A1 20001213; AU 8253598 A 19990104; CA 2293706 A1 19981223; CA 2293706 C 20081118; CN 1267291 A 20000920; CO 4940458 A1 20000724; EP 0989979 A1 20000405; HU P0002954 A2 20010628; HU P0002954 A3 20021128; IL 133389 A0 20010430; JP 2002506444 A 20020226; KR 20010013881 A 20010226; NZ 501571 A 20020201; PE 82799 A1 19990826; ZA 985205 B 19981215
DOCDB simple family (application)
US 9811507 W 19980615; AR P980102858 A 19980616; AU 8253598 A 19980615; CA 2293706 A 19980615; CN 98808189 A 19980615; CO 98034144 A 19980616; EP 98932717 A 19980615; HU P0002954 A 19980615; IL 13338998 A 19980615; JP 50450299 A 19980615; KR 19997011903 A 19991216; NZ 50157198 A 19980615; PE 00050698 A 19980615; ZA 985205 A 19980615