Global Patent Index - EP 0989979 A1

EP 0989979 A1 20000405 - NOVEL N-SUBSTITUTED UREA INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

NOVEL N-SUBSTITUTED UREA INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

N-SUBSTITUIERTE HARNSTOFF DERIVATE ALS INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE

Title (fr)

NOUVEAUX COMPOSES D'UREE N-SUBSTITUES INHIBITEURS DE LA FARNESYL TRANSFERASE

Publication

EP 0989979 A1 20000405 (EN)

Application

EP 98932717 A 19980615

Priority

  • US 9811507 W 19980615
  • US 87704997 A 19970617

Abstract (en)

[origin: WO9857948A1] Novel halo-N-substituted urea compounds and pharmaceutical compositions of formula (1.0) or a pharmaceutically acceptable salt or solvate theroef, are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

IPC 1-7

C07D 401/04; C07D 221/16; A61K 31/55; A61K 31/435

IPC 8 full level

A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)

CPC (source: EP KR)

A61P 35/00 (2017.12 - EP); C07D 401/04 (2013.01 - KR); C07D 401/12 (2013.01 - EP); C07D 401/14 (2013.01 - EP)

Citation (search report)

See references of WO 9857948A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9857948 A1 19981223; AR 013094 A1 20001213; AU 8253598 A 19990104; CA 2293706 A1 19981223; CA 2293706 C 20081118; CN 1267291 A 20000920; CO 4940458 A1 20000724; EP 0989979 A1 20000405; HU P0002954 A2 20010628; HU P0002954 A3 20021128; IL 133389 A0 20010430; JP 2002506444 A 20020226; KR 20010013881 A 20010226; NZ 501571 A 20020201; PE 82799 A1 19990826; ZA 985205 B 19981215

DOCDB simple family (application)

US 9811507 W 19980615; AR P980102858 A 19980616; AU 8253598 A 19980615; CA 2293706 A 19980615; CN 98808189 A 19980615; CO 98034144 A 19980616; EP 98932717 A 19980615; HU P0002954 A 19980615; IL 13338998 A 19980615; JP 50450299 A 19980615; KR 19997011903 A 19991216; NZ 50157198 A 19980615; PE 00050698 A 19980615; ZA 985205 A 19980615