Global Patent Index - EP 0989979 A1

EP 0989979 A1 2000-04-05 - NOVEL N-SUBSTITUTED UREA INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

NOVEL N-SUBSTITUTED UREA INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

N-SUBSTITUIERTE HARNSTOFF DERIVATE ALS INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE

Title (fr)

NOUVEAUX COMPOSES D'UREE N-SUBSTITUES INHIBITEURS DE LA FARNESYL TRANSFERASE

Publication

EP 0989979 A1 (EN)

Application

EP 98932717 A

Priority

  • US 9811507 W
  • US 87704997 A

Abstract (en)

[origin: WO9857948A1] Novel halo-N-substituted urea compounds and pharmaceutical compositions of formula (1.0) or a pharmaceutically acceptable salt or solvate theroef, are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

IPC 1-7 (main, further and additional classification)

C07D 401/04; A61K 31/435; A61K 31/55; C07D 221/16

IPC 8 full level (invention and additional information)

A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)

CPC (invention and additional information)

C07D 401/12 (2013.01); C07D 401/14 (2013.01)

Citation (search report)

See references of WO 9857948A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9857948 A1 19981223; AR 013094 A1 20001213; AU 8253598 A 19990104; CA 2293706 A1 19981223; CA 2293706 C 20081118; CN 1267291 A 20000920; CO 4940458 A1 20000724; EP 0989979 A1 20000405; HU 0002954 A2 20010628; HU 0002954 A3 20021128; IL 133389 D0 20010430; JP 2002506444 A 20020226; KR 20010013881 A 20010226; NZ 501571 A 20020201; PE 82799 A1 19990826; ZA 9805205 B 19981215

INPADOC legal status


2009-11-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20090602

2007-01-19 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1024908

2003-04-02 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030212

2000-04-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991227

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-04-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LV PAYMENT 19991227;RO PAYMENT 19991227;SI PAYMENT 19991227