Global Patent Index - EP 0989981 A1

EP 0989981 A1 2000-04-05 - NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

PHENYL-SUBSTITUIERTE TRIZYKLISCHE INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE

Title (fr)

NOUVEAUX COMPOSES TRICYCLIQUES DE PHENYLE SUBSTITUES INHIBITEURS DE FARNESYL PROTEINE TRANSFERASE

Publication

EP 0989981 A1 (EN)

Application

EP 98932719 A

Priority

  • US 9811509 W
  • US 87705297 A

Abstract (en)

[origin: WO9857950A1] Novel phenyl-substituted tricyclic compounds of formula (1.0) and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

IPC 1-7 (main, further and additional classification)

C07D 401/04; A61K 31/435; A61K 31/55; C07D 221/16

IPC 8 full level (invention and additional information)

A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)

CPC (invention and additional information)

C07D 401/12 (2013.01); C07D 401/14 (2013.01)

Citation (search report)

See references of WO 9857950A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9857950 A1 19981223; AU 8253798 A 19990104; CA 2293549 A1 19981223; CA 2293549 C 20080805; CN 1267292 A 20000920; EP 0989981 A1 20000405; HU 0003215 A2 20010628; IL 133446 D0 20010430; JP 2002504150 A 20020205; KR 20010013945 A 20010226; NZ 501613 A 20011130

INPADOC legal status


2007-10-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20070503

2007-01-19 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1024906

2003-04-02 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030213

2000-04-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991227

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-04-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LT PAYMENT 19991227;LV PAYMENT 19991227;RO PAYMENT 19991227