EP 0989981 A1 20000405 - NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Title (en)
NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Title (de)
PHENYL-SUBSTITUIERTE TRIZYKLISCHE INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE
Title (fr)
NOUVEAUX COMPOSES TRICYCLIQUES DE PHENYLE SUBSTITUES INHIBITEURS DE FARNESYL PROTEINE TRANSFERASE
Publication
Application
Priority
- US 9811509 W 19980615
- US 87705297 A 19970617
Abstract (en)
[origin: WO9857950A1] Novel phenyl-substituted tricyclic compounds of formula (1.0) and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
IPC 1-7
IPC 8 full level
A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 401/12 (2013.01 - EP); C07D 401/14 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9857950 A1 19981223; AU 8253798 A 19990104; CA 2293549 A1 19981223; CA 2293549 C 20080805; CN 1267292 A 20000920; EP 0989981 A1 20000405; HU P0003215 A2 20010628; IL 133446 A0 20010430; JP 2002504150 A 20020205; KR 20010013945 A 20010226; NZ 501613 A 20011130
DOCDB simple family (application)
US 9811509 W 19980615; AU 8253798 A 19980615; CA 2293549 A 19980615; CN 98808215 A 19980615; EP 98932719 A 19980615; HU P0003215 A 19980615; IL 13344698 A 19980615; JP 50450399 A 19980615; KR 19997011970 A 19991217; NZ 50161398 A 19980615