Global Patent Index - EP 0989986 A1

EP 0989986 A1 2000-04-05 - 5,7-DISUBSTITUTED 4-AMINOPYRIDO 2,3-D PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS

Title (en)

5,7-DISUBSTITUTED 4-AMINOPYRIDO 2,3-D PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS

Title (de)

5,7-DISUBSTITIERTE 4-AMINOPYRIDO¬2,3-D PYRIMIDINE VERBINDUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER ADENOSIN KINASE

Title (fr)

COMPOSES DE 4-AMINOPYRIDO 2,3-D PYRIMIDINE 5,7-DISUBSTITUES ET LEUR UTILISATION COMME INHIBITEURS DE L'ADENOSINE KINASE

Publication

EP 0989986 A1 (EN)

Application

EP 98918093 A

Priority

  • US 9807207 W
  • US 83821697 A

Abstract (en)

[origin: WO9846605A1] A method for inhibiting adenosine kinase by administering a compound having formula (I) wherein R<1> and R<2> are independently selected from H, loweralkyl, C1-C6alkoxyC1-C6alkyl, arylC1-C6alkyl, -C(O)C1-C6alkyl, -C(O)aryl, -C(O)heterocyclic or may join together with the nitrogen to which they are attached to form a 5-7 membered ring optionally containing 1-2 additional heteroatoms selected from O, N or S; R<3> is selected from the group consisting of loweralkyl, loweralkenyl, loweralkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group, heteroarylalkyl or heterocycloalkyl wherein the heteroaryl and heterocyclic groups are linked directly or indirectly by a ring carbon; R<4> is selected from the group consisting of loweralkyl, loweralkenyl, loweralkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group heteroarylalkyl or heterocycloalkyl; and a dashed line --- indicates that a double bond is optionally present provided that proper valencies are maintained, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, and a method of treating cerebral ischemia, epilepsy, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, a process for preparing said compounds, and compounds having the above formula wherein R<1>, R<2>, R<3> and R<4> are separately defined.

IPC 1-7 (main, further and additional classification)

C07D 471/04; A61K 31/495

IPC 8 full level (invention and additional information)

A61K 31/519 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)

CPC (invention and additional information)

A61K 31/5377 (2013.01); A61K 31/519 (2013.01); C07D 471/04 (2013.01)

Citation (search report)

See references of WO 9846605A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

Designated extension state (EPC)

RO SI

EPO simple patent family

WO 9846605 A1 19981022; AR 012436 A1 20001018; AU 7108398 A 19981111; BG 103842 A 20000630; BR 9809055 A 20000808; CA 2286909 A1 19981022; CN 1252070 A 20000503; CO 4940446 A1 20000724; EP 0989986 A1 20000405; HU 0001434 A2 20001028; HU 0001434 A3 20010129; IL 131618 D0 20010128; JP 2001520655 A 20011030; KR 20010006509 A 20010126; NO 995036 A 19991015; NO 995036 D0 19991015; PL 336304 A1 20000619; SK 141799 A3 20000814; TR 199902455 T2 20000121; ZA 9803177 B 19990122

INPADOC legal status


2007-11-14 [RTI1] TITLE (CORRECTION)

- Free text: 5,7-DISUBSTITUTED 4-AMINOPYRIDO 2,3-D PYRIMIDINE COMPOUNDS AND THEIR USE AS ADENOSINE KINASE INHIBITORS

2000-12-27 [18W] APPLICATION WITHDRAWN

- Date of withdrawal: 20001019

2000-05-31 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: BHAGWAT, SHRIPAD, S.

2000-05-31 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LEE, CHIH-HUNG

2000-05-31 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: COWART, MARLON, D.

2000-05-31 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: MCKIE, JEFFREY

2000-05-31 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: GRILLOT, ANNE, LAURE

2000-04-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991110

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-04-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: RO PAYMENT 19991110;SI PAYMENT 19991110