Title (en)

SCREENING FOR PHOSPHATIDYLINOSITOL RELATED-KINASE INHIBITORS

Title (de)

SCREENING AUF INHIBITOREN DER PHOSPHATIDYLINOSITOL VERWANDTEN KINASE

Title (fr)

CRIBLAGE D'INHIBITEURS DE LA KINASE LIEE AU PHOSPHATIDILYNOSITOL

Publication

EP 0990028 A4 20000927 (EN)

Application

EP 98930061 A 19980605

Priority

• US 9811420 W 19980605
• US 4886997 P 19970606

Abstract (en)

[origin: WO9855602A1] A method for identifying a compound inhibiting the phosphorylation activity of a phosphoinositide 3-kinase related kinase polypeptide is described. Antibodies having specific binding affinity for a conjugate including wortmannin are also described.

IPC 1-7

C12N 9/12; C12Q 1/48; C12Q 1/50

IPC 8 full level

C12N 9/12 (2006.01); C12Q 1/48 (2006.01)

CPC (source: EP)

C12N 9/1205 (2013.01); C12Q 1/48 (2013.01); G01N 2333/91215 (2013.01)

Citation (search report)

• [X] BRUNN, GREGORY J. ET AL: "Phosphorylation of the translational repressor PHAS -I by the mammalian target of rapamycin.", SCIENCE (WASHINGTON D C), (1997) VOL. 277, NO. 5322, PP. 99-101., XP000891365
• [DX] BRUNN, GREGORY J. ET AL: "Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3- kinase inhibitors, wortmannin and LY294002.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, (1996) VOL. 15, NO. 19, PP. 5256-5267., XP000891362
• See references of WO 9855602A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9855602 A1 19981210; WO 9855602 A9 19990408; AU 7953598 A 19981221; CA 2292540 A1 19981210; EP 0990028 A1 20000405; EP 0990028 A4 20000927

DOCDB simple family (application)

US 9811420 W 19980605; AU 7953598 A 19980605; CA 2292540 A 19980605; EP 98930061 A 19980605