Global Patent Index - EP 0990042 A1

EP 0990042 A1 2000-04-05 - REGULATORY SEQUENCES INVOLVED IN HYPOXIA REGULATED GENE EXPRESSION AND USES THEREOF

Title (en)

REGULATORY SEQUENCES INVOLVED IN HYPOXIA REGULATED GENE EXPRESSION AND USES THEREOF

Title (de)

REGULATORISCHE SEQUENZEN BETEILIGT AN DER HYPOXIA-REGULIERTEN GENEXPRESSION UND DEREN ANWENDUNGEN

Title (fr)

SEQUENCES REGULATRICES IMPLIQUEES DANS L'EXPRESSION GENIQUE REGULEE PAR L'HYPOXIE ET LEURS UTILISATIONS

Publication

EP 0990042 A1 (EN)

Application

EP 98936322 A

Priority

  • EP 9803517 W
  • EP 97109418 A

Abstract (en)

[origin: WO9856936A1] Described are recombinant DNA molecules comprising regulatory sequence(s) of the Vascular Endothelial Growth Factor (VEGF) gene or of a gene homologous to the VEGF gene, being capable of modulating hypoxia inducible expression of a heterologous DNA sequence in vivo. Vectors comprising said recombinant DNA molecules are provided. Also provided are pharmaceutical and diagnostic compositions comprising such recombinant DNA molecules and vectors. Furthermore, cells and transgenic non-human animals, comprising the aforementioned recombinant DNA molecules or vectors stably integrated into their genome and their use for the identification of substances capable of suppressing or activating transcription of a hypoxia inducible gene are described. Described is furthermore the use of the before described recombinant DNA molecules and vectors for the preparation of pharmaceutical compositions for treating, preventing, and/or delaying a vascular or tumorous disease in a subject. Furthermore, uses of the recombinant DNA molecules and vectors of the invention for the preparation of pharmaceutical compositions for inducing a vascular or tumorous disease in a non-human animal are provided. In addition, methods for identifying agonists/activators or antagonists/inhibitors of genes or gene products involved in hypoxia and/or ischemia, compounds identifiable by said method, antibodies directed to said compounds as well as to pharmaceutical and diagnostic compositions comprising said agonists/activators, antagonists/inhibitors and/or antibodies are described. Such compositions may be useful for the treatment or prevention or for diagnosing of vascular diseases.

IPC 1-7 (main, further and additional classification)

C12N 15/85; A01K 67/027; A61K 31/70; C07K 14/52; C12Q 1/68

IPC 8 full level (invention and additional information)

C07K 14/52 (2006.01); C12N 15/85 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/52 (2013.01); C12N 15/85 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); C12N 2830/002 (2013.01); C12N 2830/008 (2013.01); C12N 2830/85 (2013.01)

Citation (search report)

See references of WO 9856936A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9856936 A1 19981217; WO 9856936 A9 19990408; AU 8536998 A 19981230; EP 0990042 A1 20000405

INPADOC legal status


2003-07-02 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030103

2000-06-28 [RIN1] INVENTOR (CORRECTION)

- Inventor name: RISAU, BARBARA

2000-06-28 [RIN1] INVENTOR (CORRECTION)

- Inventor name: DAMERT, ANNETTE

2000-06-28 [RIN1] INVENTOR (CORRECTION)

- Inventor name: PLATE, KARL

2000-04-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000105

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE