Global Patent Index - EP 0990051 A1

EP 0990051 A1 2000-04-05 - IDENTIFICATION OF MOLECULAR TARGETS

Title (en)

IDENTIFICATION OF MOLECULAR TARGETS

Title (de)

IDENTIFIKATION VON MOLEKULARTARGETS

Title (fr)

IDENTIFICATION DE CIBLES MOLECULAIRES

Publication

EP 0990051 A1 (EN)

Application

EP 98945752 A

Priority

  • US 9814082 W
  • US 5178097 P
  • US 5178197 P

Abstract (en)

[origin: WO9902733A1] Identification of the molecular targets of a drug or toxin is the first step in understanding how the drug or toxin works, and important advance in learning how to improve a drug or assess the risks due to a toxin. The primary action of a drug usually involves binding to a protein; secondary actions may express themselves in the form of side effects and in some cases may be due to binding to other proteins. Consequently, it is useful to identify all physiologically relevant sites of action of a drug or toxin. A simple method for obtaining a list of the potential targets of a drug, toxin or other biologically active substance (referred to collectively as ligands) involves a multistep process. The first step is screeening a protein or peptide library to identify library members that exhibit high affinity for a particular ligand. The second step involves searching of sequence data bases for proteins that contain the sequences of the library members shown to have high affinity for the ligand. The proteins thus identified constitute a list of potential targets for the ligand. If random peptide libraries have been used, the position of identified consensus sequences within the identified protein constitutes an identification of the potential ligand binding site on the target.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; G01N 33/536

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12Q 1/68 (2006.01); C40B 40/02 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

C40B 40/02 (2013.01); C12N 15/1037 (2013.01); C12Q 1/6811 (2013.01); G01N 33/68 (2013.01)

Citation (search report)

See references of WO 9902733A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9902733 A1 19990121; EP 0990051 A1 20000405; JP 2003524364 A 20030819

INPADOC legal status


2002-09-18 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20020201

2000-04-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000204

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE