Global patent index - EP 0991420 A1

EP 0991420 A1 2000-04-12 - MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL-ADIPOSE AXIS WITH LEPTIN RECEPTOR LIGANDS

Title (en)

MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL-ADIPOSE AXIS WITH LEPTIN RECEPTOR LIGANDS

Title (de)

BEEINFLUSSUNG DER HYPOTHALAMUS-HYPOPHYSE-ADRENAL-ADIPOSE WECHSELWIRKUNG MIT LEPTIN-REZEPTOR LIGANDEN

Title (fr)

MODULATION DE L'AXE HYPOTALAMO-HYPOPHYSO-ADRENALO-ADIPEUX AU MOYEN DE LIGANDS DU RECEPTEUR DE LA LEPTINE

Publication

EP 0991420 A1 (EN)

Application

EP 98908553 A

Priority

  • US 9802906 W
  • US 80466997 A

Abstract (en)

[origin: WO9836767A1] This invention relates generally to a method for modulating the Hypothalamic-Pituitary-Adrenal Adipose Axis (HPAAA) in a mammal in need of such treatment by administration of a therapeutically effective amount of a leptin receptor ligand. More specifically, this invention relates to the use of leptin receptor agonists to treat disorders of the HPAAA, including the hyperglucocorticoidemia associated with Cushing's Syndrome, fasting, or otherwise-induced stress in obese or lean mammals in need of such treatment. This invention also relates to the use of leptin receptor antagonists, or specific anti-leptin antibodies, to treat the hypoglucocorticoidemia associated with autoimmune or inflammatory conditions such as rheumatoid arthritis.

IPC 1-7 (main, further and additional classification)

A61K 38/16; C07K 14/00; C07K 14/435

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61P 3/04 (2006.01); A61P 5/44 (2006.01); A61P 5/46 (2006.01); A61P 29/00 (2006.01); C07K 14/47 (2006.01)

CPC (invention and additional information)

A61K 38/2264 (2013.01)

Citation (search report)

See references of WO 9836767A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

EPO simple patent family

WO 9836767 A1 19980827; AU 6655898 A 19980909; CA 2282341 A1 19980827; EP 0991420 A1 20000412; JP 2001514620 A 20010911

INPADOC legal status

2003-07-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020902

2000-04-12 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990906

2000-04-12 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE