EP 0991420 A1 20000412 - MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL-ADIPOSE AXIS WITH LEPTIN RECEPTOR LIGANDS
Title (en)
MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL-ADIPOSE AXIS WITH LEPTIN RECEPTOR LIGANDS
Title (de)
BEEINFLUSSUNG DER HYPOTHALAMUS-HYPOPHYSE-ADRENAL-ADIPOSE WECHSELWIRKUNG MIT LEPTIN-REZEPTOR LIGANDEN
Title (fr)
MODULATION DE L'AXE HYPOTALAMO-HYPOPHYSO-ADRENALO-ADIPEUX AU MOYEN DE LIGANDS DU RECEPTEUR DE LA LEPTINE
Publication
Application
Priority
- US 9802906 W 19980224
- US 80466997 A 19970225
Abstract (en)
[origin: WO9836767A1] This invention relates generally to a method for modulating the Hypothalamic-Pituitary-Adrenal Adipose Axis (HPAAA) in a mammal in need of such treatment by administration of a therapeutically effective amount of a leptin receptor ligand. More specifically, this invention relates to the use of leptin receptor agonists to treat disorders of the HPAAA, including the hyperglucocorticoidemia associated with Cushing's Syndrome, fasting, or otherwise-induced stress in obese or lean mammals in need of such treatment. This invention also relates to the use of leptin receptor antagonists, or specific anti-leptin antibodies, to treat the hypoglucocorticoidemia associated with autoimmune or inflammatory conditions such as rheumatoid arthritis.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61P 3/04 (2006.01); A61P 5/44 (2006.01); A61P 5/46 (2006.01); A61P 29/00 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
A61K 38/2264 (2013.01); A61P 3/04 (2017.12); A61P 5/44 (2017.12); A61P 5/46 (2017.12); A61P 29/00 (2017.12)
Citation (search report)
See references of WO 9836767A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9836767 A1 19980827; AU 6655898 A 19980909; CA 2282341 A1 19980827; EP 0991420 A1 20000412; JP 2001514620 A 20010911
DOCDB simple family (application)
US 9802906 W 19980224; AU 6655898 A 19980224; CA 2282341 A 19980224; EP 98908553 A 19980224; JP 53674898 A 19980224