Global Patent Index - EP 0991420 A1

EP 0991420 A1 20000412 - MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL-ADIPOSE AXIS WITH LEPTIN RECEPTOR LIGANDS

Title (en)

MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL-ADIPOSE AXIS WITH LEPTIN RECEPTOR LIGANDS

Title (de)

BEEINFLUSSUNG DER HYPOTHALAMUS-HYPOPHYSE-ADRENAL-ADIPOSE WECHSELWIRKUNG MIT LEPTIN-REZEPTOR LIGANDEN

Title (fr)

MODULATION DE L'AXE HYPOTALAMO-HYPOPHYSO-ADRENALO-ADIPEUX AU MOYEN DE LIGANDS DU RECEPTEUR DE LA LEPTINE

Publication

EP 0991420 A1 20000412 (EN)

Application

EP 98908553 A 19980224

Priority

  • US 9802906 W 19980224
  • US 80466997 A 19970225

Abstract (en)

[origin: WO9836767A1] This invention relates generally to a method for modulating the Hypothalamic-Pituitary-Adrenal Adipose Axis (HPAAA) in a mammal in need of such treatment by administration of a therapeutically effective amount of a leptin receptor ligand. More specifically, this invention relates to the use of leptin receptor agonists to treat disorders of the HPAAA, including the hyperglucocorticoidemia associated with Cushing's Syndrome, fasting, or otherwise-induced stress in obese or lean mammals in need of such treatment. This invention also relates to the use of leptin receptor antagonists, or specific anti-leptin antibodies, to treat the hypoglucocorticoidemia associated with autoimmune or inflammatory conditions such as rheumatoid arthritis.

IPC 1-7

A61K 38/16; C07K 14/00; C07K 14/435

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61P 3/04 (2006.01); A61P 5/44 (2006.01); A61P 5/46 (2006.01); A61P 29/00 (2006.01); C07K 14/47 (2006.01)

CPC (source: EP)

A61K 38/2264 (2013.01); A61P 3/04 (2017.12); A61P 5/44 (2017.12); A61P 5/46 (2017.12); A61P 29/00 (2017.12)

Citation (search report)

See references of WO 9836767A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family (publication)

WO 9836767 A1 19980827; AU 6655898 A 19980909; CA 2282341 A1 19980827; EP 0991420 A1 20000412; JP 2001514620 A 20010911

DOCDB simple family (application)

US 9802906 W 19980224; AU 6655898 A 19980224; CA 2282341 A 19980224; EP 98908553 A 19980224; JP 53674898 A 19980224