EP 0991642 A1 20000412 - 2-AMINOALKYLAMINOQUINOLINES AS DOPAMINE D4 LIGANDS
Title (en)
2-AMINOALKYLAMINOQUINOLINES AS DOPAMINE D4 LIGANDS
Title (de)
2-AMINOALKYLAMINOCHINOLINE ALS DOPAMINE D4 LIGANDEN
Title (fr)
2-AMINOALKYLAMINOQUINOLEINES UTILISEES COMME LIGANDS DE LA DOPAMINE D4
Publication
Application
Priority
- US 9814235 W 19980611
- US 87486497 A 19970613
Abstract (en)
[origin: WO9856786A1] A compound of formula (IA) or the pharmaceutically acceptable acid addition salts thereof wherein: R1, R2, R3, R4 and R5 are the same or different and represent hydrogen, halogen, C1-C6alkyl, C1-C4alkoxy, C1-C4alkylthio, hydroxy, amino, mono(C1-C6) alkylamino, di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; R6 is hydrogen or C1-C6alkyl; W is nitrogen, COH, or CH; Y and Z independently represent nitrogen or CH; and A represents an alkylene group of from 2-5 carbon atoms optionally substituted with one or more alkyl groups having from one to four carbon atoms. The compounds of the invention demonstrate high affinity and selectivity in binding to the D4 receptor subtype.
IPC 1-7
IPC 8 full level
A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61P 25/00 (2006.01); A61P 25/18 (2006.01); A61P 43/00 (2006.01); C07D 215/38 (2006.01); C07D 401/12 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/18 (2017.12); A61P 43/00 (2017.12); C07D 215/38 (2013.01); C07D 401/12 (2013.01)
Citation (search report)
See references of WO 9856786A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9856786 A1 19981217; AU 8296998 A 19981230; CA 2293480 A1 19981217; EP 0991642 A1 20000412; JP 2002504125 A 20020205
DOCDB simple family (application)
US 9814235 W 19980611; AU 8296998 A 19980611; CA 2293480 A 19980611; EP 98933291 A 19980611; JP 50334399 A 19980611