Global Patent Index - EP 0991642 A1

EP 0991642 A1 2000-04-12 - 2-AMINOALKYLAMINOQUINOLINES AS DOPAMINE D4 LIGANDS

Title (en)

2-AMINOALKYLAMINOQUINOLINES AS DOPAMINE D4 LIGANDS

Title (de)

2-AMINOALKYLAMINOCHINOLINE ALS DOPAMINE D4 LIGANDEN

Title (fr)

2-AMINOALKYLAMINOQUINOLEINES UTILISEES COMME LIGANDS DE LA DOPAMINE D4

Publication

EP 0991642 A1 (EN)

Application

EP 98933291 A

Priority

  • US 9814235 W
  • US 87486497 A

Abstract (en)

[origin: WO9856786A1] A compound of formula (IA) or the pharmaceutically acceptable acid addition salts thereof wherein: R1, R2, R3, R4 and R5 are the same or different and represent hydrogen, halogen, C1-C6alkyl, C1-C4alkoxy, C1-C4alkylthio, hydroxy, amino, mono(C1-C6) alkylamino, di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; R6 is hydrogen or C1-C6alkyl; W is nitrogen, COH, or CH; Y and Z independently represent nitrogen or CH; and A represents an alkylene group of from 2-5 carbon atoms optionally substituted with one or more alkyl groups having from one to four carbon atoms. The compounds of the invention demonstrate high affinity and selectivity in binding to the D4 receptor subtype.

IPC 1-7 (main, further and additional classification)

C07D 401/12; A61K 31/47; C07D 215/38

IPC 8 full level (invention and additional information)

A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61P 25/00 (2006.01); A61P 25/18 (2006.01); A61P 43/00 (2006.01); C07D 215/38 (2006.01); C07D 401/12 (2006.01)

CPC (invention and additional information)

C07D 215/38 (2013.01); C07D 401/12 (2013.01)

Citation (search report)

See references of WO 9856786A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9856786 A1 19981217; AU 8296998 A 19981230; CA 2293480 A1 19981217; EP 0991642 A1 20000412; JP 2002504125 A 20020205

INPADOC legal status


2003-09-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030219

2002-12-18 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021106

2000-04-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000112

2000-04-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-04-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000112;LT PAYMENT 20000112;LV PAYMENT 20000112;MK PAYMENT 20000112;RO PAYMENT 20000112;SI PAYMENT 20000112