Title (en)

BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (de)

BIS-INDOLDERIVATE MIT ANTIMETASTATISCHER WIRKUNG, VERFAHREN ZU DEREN HERSTELLUNG UND SIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

Title (fr)

DERIVES DE BIS-INDOLE PRESENTANT UNE ACTIVITE ANTIMETASTASIQUE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Publication

EP 0991645 A1 20000412 (EN)

Application

EP 98937539 A 19980623

Priority

• EP 98937539 A 19980623
• EP 9803837 W 19980623
• EP 97110336 A 19970625

Abstract (en)

[origin: EP0887348A1] The present invention relates to compounds of the general formula (I): <CHEM> wherein: R and R' are independently selected from hydrogen, hydroxy, chlorine, bromine, iodine, fluorine, (C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)acyloxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, -SH, (C1-C4)alkylthio, carboxy, (C1-C4)alkoxycarbonyl groups; R1 and R1' are independently selected from hydrogen, hydroxy, hydroxymethyl, amino, carboxy, (C1-C4)alkyl groups; A is a phenyl or naphtyl group substituted by at least one group selected from hydoxy, carboxy, -SH, -CONHOH or -PO3H2 group, or is a 5- or 6-membered heterocycle containing one or two heteroatoms selected from oxygen, nitrogen or sulfur, which can be optionally benzocondensed and/or substituted by at least one group selected from pyridyl, -SH, -PO3H2, carboxy or CONHOH, or is a group of formula -(CH2)n-X, in which n is zero or the integers 1 or 2, and X is selected from -SH -PO3H2, -CONHOH, carboxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, enantiomers, diastereoisomers, racemates and mixtures thereof, as well as salts thereof with pharmaceutically acceptable acids and bases, as antitumor and antimetastatic agents. l

IPC 1-7

C07D 401/14; A61K 31/40; C07D 409/14; C07D 403/14; C07D 405/14; C07D 209/10; C07F 9/38

IPC 8 full level

A61K 31/40 (2006.01); A61K 31/404 (2006.01); A61K 31/4178 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/675 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07D 209/10 (2006.01); C07D 209/14 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07F 9/38 (2006.01); C07F 9/572 (2006.01)

CPC (source: EP KR)

A61K 31/404 (2013.01 - EP); A61K 31/4439 (2013.01 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP); C07D 209/14 (2013.01 - EP); C07D 401/14 (2013.01 - EP KR); C07D 403/14 (2013.01 - EP); C07D 405/14 (2013.01 - EP); C07D 409/14 (2013.01 - EP); C07F 9/5728 (2013.01 - EP)

Citation (search report)

See references of WO 9900381A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

EP 0887348 A1 19981230; AR 016283 A1 20010704; AU 8629598 A 19990119; BR 9810947 A 20000926; CA 2294250 A1 19990107; CN 1268134 A 20000927; CO 4940464 A1 20000724; EP 0991645 A1 20000412; HR P980357 A2 19990228; JP 2002507206 A 20020305; KR 20010014215 A 20010226; MA 26513 A1 20041220; TR 199903218 T2 20000721; WO 9900381 A1 19990107; ZA 985482 B 19991224

DOCDB simple family (application)

EP 97110336 A 19970625; AR P980103029 A 19980624; AU 8629598 A 19980623; BR 9810947 A 19980623; CA 2294250 A 19980623; CN 98808565 A 19980623; CO 98036361 A 19980625; EP 9803837 W 19980623; EP 98937539 A 19980623; HR P980357 A 19980624; JP 50527199 A 19980623; KR 19997012300 A 19991224; MA 25125 A 19980619; TR 9903218 T 19980623; ZA 985482 A 19980624