Global Patent Index - EP 0993301 A4

EP 0993301 A4 2000-04-19 - COCAINE RECEPTOR BINDING LIGANDS

Title (en)

COCAINE RECEPTOR BINDING LIGANDS

Title (de)

COCAIN-REZEPTOR BINDENDE LIGANDEN

Title (fr)

LIGANDS LIANT DES RECEPTEURS DE COCAINE

Publication

EP 0993301 A4 (EN)

Application

EP 97940580 A

Priority

  • US 9714702 W
  • US 70150396 A
  • US 70626396 A
  • US 82356397 A

Abstract (en)

[origin: WO9807427A1] The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.

IPC 1-7 (main, further and additional classification)

A61K 31/46; A61P 25/16; A61P 25/30; C07D 451/02

IPC 8 full level (invention and additional information)

A61K 31/46 (2006.01); A61P 25/00 (2006.01); A61P 25/24 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 451/02 (2006.01); C07F 7/22 (2006.01)

CPC (invention and additional information)

C07D 451/02 (2013.01); C07F 7/2208 (2013.01)

Citation (search report)

  • [Y] WO 9309814 A1 19930527 - RES TRIANGLE INST [US], et al
  • [Y] CARROLL F I ET AL: "Synthesis and ligand binding of 3.beta.-(3-substituted phenyl)- and 3.beta.-(3,4-disubstituted phenyl)tropane-2.beta.-carboxylic acid methyl esters", MED. CHEM. RES. (MCREEB,10542523);1991; VOL.1 (6); PP.382-7, Res. Triangle Inst.;Chem. Life Sci.; Research Triangle Park; 27709; NC; USA (US), XP002116826
  • [Y] CARROLL F I ET AL: "Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogs at the dopamine transporter", J. MED. CHEM. (JMCMAR,00222623);1992; VOL.35 (6); PP.969-81, Research Triangle Inst.;Research Triangle Park; 27709; NC; USA (US), XP002116827
  • [A] CARROLL F I ET AL: "Cocaine receptor-design of ligands", NIDA RES. MONOGR. (MIDAD4,03618595);1990; VOL.96 (DRUGS ABUSE: CHEM., PHARMACOL., IMMUNOL., AIDS); PP.112-21, Research Triangle Inst.;Research Triangle Park; 27709; NC; USA (US), XP002116828
  • [Y] CARROLL F I ET AL: "3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogs of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters", J. MED. CHEM. (JMCMAR,00222623);1993; VOL.36 (20); PP.2886-90, Research Triangle Inst.;Research Triangle Park; 27709; NC; USA (US), XP002116829
  • See also references of WO 9807427A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9807427 A1 19980226; AT 236635 T 20030415; AU 4232797 A 19980306; CA 2263961 A1 19980226; CA 2263961 C 20070306; DE 69720800 D1 20030515; DE 69720800 T2 20040129; EP 0993301 A1 20000419; EP 0993301 A4 20000419; EP 0993301 B1 20030409; JP 2001525795 A 20011211; JP 2009102364 A 20090514; JP 4354531 B2 20091028; US 5935953 A 19990810