Global Patent Index - EP 0994707 A1

EP 0994707 A1 2000-04-26 - INHIBITORS OF NAALADASE ENZYME ACTIVITY

Title (en)

INHIBITORS OF NAALADASE ENZYME ACTIVITY

Title (de)

INHIBITOREN DER NAALADASE-ENZYM-AKTIVITÄT

Title (fr)

INHIBITEURS DE L'ACTIVITE ENZYMATIQUE DE NAALADASE

Publication

EP 0994707 A1 (EN)

Application

EP 97937265 A

Priority

  • US 9714347 W
  • US 85898597 A
  • US 86362497 A
  • US 86454597 A
  • US 90019497 A
  • ZA 9707087 A

Abstract (en)

[origin: WO9853812A1] The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.

IPC 1-7 (main, further and additional classification)

A61K 31/34; A61K 31/38; A61K 31/405; A61K 31/44; A61K 31/66; C07D 209/04; C07D 213/16; C07D 307/34; C07D 333/04; C07F 9/22

IPC 8 full level (invention and additional information)

A61K 31/194 (2006.01); A61K 38/05 (2006.01); A61K 38/06 (2006.01); C07F 9/30 (2006.01); C07F 9/38 (2006.01)

CPC (invention and additional information)

A61K 31/661 (2013.01); A61K 31/194 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); C07F 9/301 (2013.01); C07F 9/3808 (2013.01); C07F 9/3826 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9853812 A1 19981203; EP 0994707 A1 20000426; EP 0994707 A4 20011114

INPADOC legal status


2003-07-02 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030508

2002-08-07 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020624

2001-11-14 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20010927

2001-11-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-11-14 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 61K 31/34 A, 7A 61K 31/38 B, 7A 61K 31/44 B, 7A 61K 31/66 B, 7A 61K 31/405 B, 7C 07F 9/22 B, 7C 07D 209/04 B, 7C 07D 213/16 B, 7C 07D 307/34 B, 7C 07D 333/04 B, 7C 07F 9/30 B, 7C 07F 9/38 B

2000-04-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991124

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE