EP 0994707 A1 20000426 - INHIBITORS OF NAALADASE ENZYME ACTIVITY
Title (en)
INHIBITORS OF NAALADASE ENZYME ACTIVITY
Title (de)
INHIBITOREN DER NAALADASE-ENZYM-AKTIVITÄT
Title (fr)
INHIBITEURS DE L'ACTIVITE ENZYMATIQUE DE NAALADASE
Publication
Application
Priority
- US 9714347 W 19970815
- US 85898597 A 19970527
- US 86362497 A 19970527
- US 86454597 A 19970528
- US 90019497 A 19970725
- ZA 977087 A 19970808
Abstract (en)
[origin: WO9853812A1] The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
IPC 1-7
A61K 31/34; A61K 31/38; A61K 31/44; A61K 31/66; A61K 31/405; C07F 9/22; C07D 209/04; C07D 213/16; C07D 307/34; C07D 333/04
IPC 8 full level
A61K 31/194 (2006.01); A61K 38/05 (2006.01); A61K 38/06 (2006.01); C07F 9/30 (2006.01); C07F 9/38 (2006.01)
CPC (source: EP)
A61K 31/194 (2013.01); A61K 31/661 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); C07F 9/301 (2013.01); C07F 9/3808 (2013.01); C07F 9/3826 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9853812 A1 19981203; EP 0994707 A1 20000426; EP 0994707 A4 20011114
DOCDB simple family (application)
US 9714347 W 19970815; EP 97937265 A 19970815