EP 0994715 A4 20010808 - DIFLUORONUCLEOSIDE PHOSPHONIC ACIDS AND DERIVATIVES THEREOF

Title (en)

DIFLUORONUCLEOSIDE PHOSPHONIC ACIDS AND DERIVATIVES THEREOF

Title (de)

DIFLUORNUKLEOSID-PHOSPHORSÄUREN UND IHRE DERIVATE

Title (fr)

ACIDES DIFLUORONUCLEOSIDES-PHOSPHONIQUES ET LEURS DERIVES

Publication

EP 0994715 A4 20010808 (EN)

Application

EP 98910503 A 19980319

Priority

US 9805477 W 19980319
US 4150797 P 19970324

Abstract (en)

[origin: WO9842351A1] Difluoronucleoside phosphonic acids and derivatives thereof of formula (II) where R is base selected from the group consisting of: (i), (ii), (iii), (iv), and (v) wherein R<1> is hydrogen, methyl, bromo, fluoro, chloro or iodo; R<2> is hydroxy or -NR<4>R<5>, where R<4> and R<5> are independently selected from the group consisting of hydrogen, methyl, ethyl and propyl; R<3> is hydrogen, bromo, chloro or iodo; both R<6> are the same, and are either -OR<7> or -(O<->R<8>), where R<7> is selected from the group consisting of hydrogen, methyl, ethyl, and isopropyl; R<8> is a pharmaceutically acceptable cation; and pharmaceutically acceptable salts and solvates thereof; are described and claimed as antiviral and antineoplastic agents.

IPC 1-7

A61K 31/70; C07H 19/10; C07H 19/20

IPC 8 full level

C07H 19/073 (2006.01); A61K 31/7068 (2006.01); A61K 31/7072 (2006.01); A61K 31/7076 (2006.01); A61K 31/708 (2006.01); A61P 31/12 (2006.01); A61P 31/22 (2006.01); A61P 35/00 (2006.01); C07H 19/10 (2006.01); C07H 19/173 (2006.01); C07H 19/20 (2006.01)

CPC (source: EP)

A61P 31/12 (2017.12); A61P 31/22 (2017.12); A61P 35/00 (2017.12); C07H 19/10 (2013.01); C07H 19/20 (2013.01)

Citation (search report)

[A] EP 0376518 A1 19900704 - LILLY CO ELI [US]
See references of WO 9842351A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family (publication)

WO 9842351 A1 19981001; AU 6473098 A 19981020; CA 2284263 A1 19981001; EP 0994715 A1 20000426; EP 0994715 A4 20010808; JP 2001518931 A 20011016

DOCDB simple family (application)

US 9805477 W 19980319; AU 6473098 A 19980319; CA 2284263 A 19980319; EP 98910503 A 19980319; JP 54582098 A 19980319