Global Patent Index - EP 0994857 A1

EP 0994857 A1 2000-04-26 - (1H-IMIDAZOL-4-YL)PIPERIDINE DERIVATIVES, PREPARATION AND APPLICATION IN THERAPY

Title (en)

(1H-IMIDAZOL-4-YL)PIPERIDINE DERIVATIVES, PREPARATION AND APPLICATION IN THERAPY

Title (de)

(1H-IMIDAZOL-4-YL)PIPERIDINDEIVATE, IHRE HERSTELLUNG UND IHRE MEDIZINISCHE VERWENDUNG

Title (fr)

DERIVES DE (1$i(H)-IMIDAZOL-4-YL)PIPERIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publication

EP 0994857 A1 (FR)

Application

EP 98932236 A

Priority

  • FR 9801287 W
  • FR 9708256 A

Abstract (en)

[origin: FR2765580A1] The invention concerns compounds of formula (I) in which R1 and R2 represent each independently of each other either a hydrogen atom, or a (C1-C4) linear or branched alkyl group; R3 and R4 represent each independently of each other either a hydrogen or halogen atom, or (C1-C4) alkyl group, trifluoromethyl, (C1-C4) alkoxy, S(O)pR with R a (C1-C4) linear or branched alkyl group and p = 0 to 2; and A represents either a hydrogen atom, or a (C1-C6) linear or branched alkyl group, phenyl (C1-C4)alkyl, -COR5, -COOR5, -CONHR5, -SO2R5, where R5 is a (C1-C6) linear or branched alkyl group, a (C3-C7) cycloalkyl group; a (C3-C7) cycloalkyl (C1-C5)alkyl group, a (C1-C4) alkoxy (C1-C6) alkyl group, a phenyl group, a phenyl (C1-C4) alkyl group, a phenyl (C1-C4)alkylidene group, or a -COCH2NR6R7 group where R6 is a hydrogen atom or a (C1-C4) linear or branched alkyl group and R7 a (C1-C4) linear or branched alkyl group or acyl or R1, R3 and R4 being such as defined above, A and R2 form a cycle of the type -(CH2)nCO- where n can take a value between 2 and 6, in the form of pharmaceutically acceptable free bases or addition salts to acids The invention is applicable in therapy.

IPC 1-7 (main, further and additional classification)

C07D 233/54; A61K 31/415

IPC 8 full level (invention and additional information)

A61K 31/454 (2006.01); A61P 9/00 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07D 233/54 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01)

CPC (invention and additional information)

C07D 401/04 (2013.01); C07D 401/14 (2013.01)

Citation (search report)

See references of WO 9901435A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

FR 2765580 A1 19990108; FR 2765580 B1 19990806; AR 013149 A1 20001213; AU 8220598 A 19990125; EP 0994857 A1 20000426; JP 2002507983 A 20020312; WO 9901435 A1 19990114; ZA 9805727 B 19990127

INPADOC legal status


2001-06-20 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010103

2000-04-26 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000201

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-04-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000201;LT PAYMENT 20000201;LV PAYMENT 20000201;MK PAYMENT 20000201;RO PAYMENT 20000201;SI PAYMENT 20000201