EP 0994895 A1 20000426 - DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (en)
DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (de)
DIPEPTIDE, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN
Title (fr)
COMPOSES DE DIPEPTIDES INHIBANT UNE ADHESION DE LEUCOCYTES REGULEE PAR VLA-4
Publication
Application
Priority
- US 9815314 W 19980730
- US 90441597 A 19970731
Abstract (en)
[origin: WO9906435A1] Diclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthristis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
IPC 1-7
IPC 8 full level
A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07K 5/06 (2006.01); A61K 38/00 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP KR)
A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); C07K 5/06026 (2013.01 - EP); C07K 5/06078 (2013.01 - EP); C07K 5/06139 (2013.01 - KR); C07K 5/06165 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 9906435 A1 19990211; AR 016387 A1 20010704; AU 8661298 A 19990222; BR 9811599 A 20000919; CA 2291475 A1 19990211; CN 1265673 A 20000906; EP 0994895 A1 20000426; HU P0002682 A1 20010730; HU P0002682 A3 20011228; IL 133642 A0 20010430; JP 2001512137 A 20010821; KR 20010022412 A 20010315; NO 20000412 D0 20000127; NO 20000412 L 20000324; PL 338554 A1 20001106; ZA 986834 B 20000502
DOCDB simple family (application)
US 9815314 W 19980730; AR P980103776 A 19980730; AU 8661298 A 19980730; BR 9811599 A 19980730; CA 2291475 A 19980730; CN 98807762 A 19980730; EP 98937991 A 19980730; HU P0002682 A 19980730; IL 13364298 A 19980730; JP 2000505190 A 19980730; KR 20007000992 A 20000128; NO 20000412 A 20000127; PL 33855498 A 19980730; ZA 986834 A 19980730