Global Patent Index - EP 0994896 A1

EP 0994896 A1 2000-04-26 - SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (en)

SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (de)

SULFONYLIERTE DIPEPTIDE, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN

Title (fr)

COMPOSES DIPEPTIDIQUES SULFONYLES INHIBITEURS DE L'ADHESION DES LEUCOCYTES INDUITE PAR VLA-4

Publication

EP 0994896 A1 (EN)

Application

EP 98939871 A

Priority

  • US 9816070 W
  • US 90442397 A

Abstract (en)

[origin: WO9906437A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

IPC 1-7 (main, further and additional classification)

C07K 5/078; A61K 38/05

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61K 38/00 (2006.01); A61P 9/00 (2006.01); A61P 43/00 (2006.01); C07K 5/06 (2006.01); C07K 5/078 (2006.01)

CPC (invention and additional information)

C07K 5/06165 (2013.01); C07K 5/06139 (2013.01); C07K 5/06191 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9906437A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906437 A1 19990211; AU 8823498 A 19990222; BR 9811594 A 20000905; CA 2290748 A1 19990211; CN 1265672 A 20000906; EP 0994896 A1 20000426; HU 0003921 A2 20010228; HU 0003921 A3 20010328; IL 133637 D0 20010430; JP 2001512139 A 20010821; NO 20000452 A 20000327; NO 20000452 D0 20000128; PL 338457 A1 20001106

INPADOC legal status


2007-03-09 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1026434

2003-08-13 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030201

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: THORSETT, EUGENE, D.

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SEMKO, CHRISTOPHER, M.

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: PLEISS, MICHAEL, A.

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KREFT, ANTHONY

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KONRADI, ANDREI, W.

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GRANT, FRANCINE, S.

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: BAUDY, REINHARDT, BERNHARD

2000-07-05 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SARANTAKIS, DIMITRIOS

2000-04-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000225

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-04-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000225;LT PAYMENT 20000225;LV PAYMENT 20000225;MK PAYMENT 20000225;RO PAYMENT 20000225;SI PAYMENT 20000225