EP 0994946 A1 20000426 - CODING SEQUENCE HAPLOTYPES OF THE HUMAN BRCA2 GENE
Title (en)
CODING SEQUENCE HAPLOTYPES OF THE HUMAN BRCA2 GENE
Title (de)
MENSCHLICHE BRCA2 GEN KODIERENDE SEQUENZ HAPLOTYPEN
Title (fr)
HAPLOTYPES D'UNE SEQUENCE CODANTE DU GENE HUMAIN BRCA2
Publication
Application
Priority
- US 9816905 W 19980814
- US 5578497 P 19970815
- US 6492697 P 19971107
- US 6536797 P 19971112
- US 7171598 A 19980501
- US 8447198 A 19980522
Abstract (en)
[origin: WO9909164A1] Five DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2<(omi1-5)> and the ten polymorphic sites will provide accuracy and reliability for genetic testing. One skilled in the art will be able to avoid misinterpretations of changes in the gene and/or protein sequence, determine the presence of a normal sequence, and of mutations of BRCA2. This invention is also related to a method of performing gene therapy with BRCA2<(omi1-5)> coding sequences or fragments thereof. This invention is further related to protein therapy with BRCA2<(omi1-5)> proteins or their functional equivalents.
IPC 1-7
C12N 15/12; C07K 14/47; C12Q 1/68; A61K 48/00; C07K 16/18; A61K 38/17
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 37/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/4703 (2013.01); C12Q 1/6806 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12Q 1/6886 (2013.01); C12Q 2539/105 (2013.01)
Citation (search report)
See references of WO 9909164A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9909164 A1 19990225; WO 9909164 A9 19990506; AU 9292898 A 19990308; EP 0994946 A1 20000426; EP 2275574 A2 20110119; EP 2275574 A3 20120627; EP 2275574 B1 20150603; EP 2275575 A2 20110119; EP 2275575 A3 20120711; IL 134505 A0 20010430; JP 2001514887 A 20010918; JP 2009118863 A 20090604; JP 2013143958 A 20130725
DOCDB simple family (application)
US 9816905 W 19980814; AU 9292898 A 19980814; EP 10175317 A 19980814; EP 10175418 A 19980814; EP 98945756 A 19980814; IL 13450598 A 19980814; JP 2000509828 A 19980814; JP 2009058788 A 20090311; JP 2013064698 A 20130326