Global patent index - EP 0994958 A2

EP 0994958 A2 2000-04-26 - SELECTIVE REGULATION OF ADENOVIRUS PRODUCTION

Title (en)

SELECTIVE REGULATION OF ADENOVIRUS PRODUCTION

Title (de)

SLEKTIVE REGELUNG FÜR PRODUKTIONSVERFAHREN VON ADENOVIRUS

Title (fr)

REGULATION SELECTIVE DE LA PRODUCTION D'ADENOVIRUS

Publication

EP 0994958 A2 (EN)

Application

EP 99917543 A

Priority

  • US 9908294 W
  • US 8186798 P
  • US 8832198 P

Abstract (en)

[origin: WO9953085A2] The present invention relates to adenovirus vectors and their use in DNA delivery systems. The vectors have been designed to maximize their capacity to carry foreign DNA and to minimize the potential of producing replication competent virus. The vectors contain one or more copies of a minimum packaging sequence to direct virus packaging. Optionally, the vectors contain one or more repressor binding sites so that virion production can be selectively inhibited. Specific repression systems include COUP-TF and DOLLAR I(lac) repressor. A cellular complex, called P complex is also disclosed. This complex functions positively in viral packaging and virus production.

IPC 1-7 (main, further and additional classification)

C12N 15/86

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); C12N 5/10 (2006.01); C12N 15/861 (2006.01)

CPC (invention and additional information)

C12N 15/86 (2013.01); C12N 2710/10343 (2013.01)

Citation (search report)

See references of WO 9953085A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9953085 A2 19991021; WO 9953085 A3 20000127; AU 3563699 A 19991101; AU 770005 B2 20040212; EP 0994958 A2 20000426; IL 133510 D0 20010430; JP 2002506355 A 20020226; NZ 502175 A 20021220

INPADOC legal status

2004-05-26 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20031101

2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000509

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE