EP 0994958 A2 20000426 - SELECTIVE REGULATION OF ADENOVIRUS PRODUCTION
Title (en)
SELECTIVE REGULATION OF ADENOVIRUS PRODUCTION
Title (de)
SLEKTIVE REGELUNG FÜR PRODUKTIONSVERFAHREN VON ADENOVIRUS
Title (fr)
REGULATION SELECTIVE DE LA PRODUCTION D'ADENOVIRUS
Publication
Application
Priority
- US 9908294 W 19990415
- US 8186798 P 19980415
- US 8832198 P 19980605
Abstract (en)
[origin: WO9953085A2] The present invention relates to adenovirus vectors and their use in DNA delivery systems. The vectors have been designed to maximize their capacity to carry foreign DNA and to minimize the potential of producing replication competent virus. The vectors contain one or more copies of a minimum packaging sequence to direct virus packaging. Optionally, the vectors contain one or more repressor binding sites so that virion production can be selectively inhibited. Specific repression systems include COUP-TF and DOLLAR I(lac) repressor. A cellular complex, called P complex is also disclosed. This complex functions positively in viral packaging and virus production.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/76 (2015.01); A61K 35/761 (2015.01); A61K 48/00 (2006.01); C12N 5/10 (2006.01); C12N 15/861 (2006.01)
CPC (source: EP)
C12N 15/86 (2013.01); C12N 2710/10343 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9953085 A2 19991021; WO 9953085 A3 20000127; AU 3563699 A 19991101; AU 770005 B2 20040212; EP 0994958 A2 20000426; IL 133510 A0 20010430; JP 2002506355 A 20020226; NZ 502175 A 20021220
DOCDB simple family (application)
US 9908294 W 19990415; AU 3563699 A 19990415; EP 99917543 A 19990415; IL 13351099 A 19990415; JP 55211099 A 19990415; NZ 50217599 A 19990415