Global Patent Index - EP 0994959 A1

EP 0994959 A1 2000-04-26 - POLYMER-MODIFIED VIRUSES

Title (en)

POLYMER-MODIFIED VIRUSES

Title (de)

POLYMER-MODIFIZIERTE VIREN

Title (fr)

VIRUS MODIFIES PAR DES POLYMERES

Publication

EP 0994959 A1 (EN)

Application

EP 98914467 A

Priority

  • GB 9706735 A
  • GB 9719625 A
  • GB 9722316 A
  • US 9806609 W

Abstract (en)

[origin: WO9844143A1] The present invention relates to polymer-modified viruses, processes for obtaining them and their use. In a preferred embodiment the polymer is polyethylene glycol (PEG). In one embodiment, the polymer is directly covalently attached to the virus. In another embodiment, the polymer is indirectly covalently attached to the virus via an intermediate coupling moiety. In yet another embodiment, the polymer is indirectly noncovalently attached to the virus via a ligand. In a preferred embodiment, the ligand has specificity for a viral surface component. For example, the ligand may be an antibody. The present invention further provides a method of making viruses modified by polymers, whereby the modified viruses retain infectivity. Another embodiment of the present invention provides a method for introducing a transgene into a target cell comprising contacting the target cell with a polymer-modified virus, wherein the virus comprises the transgene. The present invention further provides a method of delivering a virus to a tumor, comprising administering a polymer-modified virus of the invention to a subject in need of such treatment under conditions whereby the polymer-modified virus localizes to a tumor. In another embodiment, the present invention provides a composition comprising a virus modified by a polymer and a carrier.

IPC 1-7 (main, further and additional classification)

C12N 15/87; A61K 39/385; A61K 48/00; A61K 47/48

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 39/385 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01)

CPC (invention and additional information)

C12N 15/86 (2013.01); A61K 47/6901 (2017.08); A61K 48/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); C12N 2710/16645 (2013.01); C12N 2710/24145 (2013.01); C12N 2740/13045 (2013.01); C12N 2810/10 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9844143 A1 19981008; WO 9844143 A9 19990422; AU 6881798 A 19981022; AU 745056 B2 20020307; CA 2285416 A1 19981008; EP 0994959 A1 20000426; JP 2001521381 A 20011106

INPADOC legal status


2007-04-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20061031

2000-04-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991021

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE