Global patent index - EP 0996432 A2

EP 0996432 A2 2000-05-03 - BIOLOGICALLY ACTIVE 1,3-BIS-AROMATIC-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIC-PROPAN-1-ONES, AND 1,3-BIS-AROMATIC-PROP-2-YN-1-ONES

Title (en)

BIOLOGICALLY ACTIVE 1,3-BIS-AROMATIC-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIC-PROPAN-1-ONES, AND 1,3-BIS-AROMATIC-PROP-2-YN-1-ONES

Title (de)

BIOLOGISCH-WIRKSAME 1,3-BIS-AROMATISCHE-PROP-2-EN-1-ON, 1,3-BIS-AROMATISCHE-PROPAN-1-ON, AND 1,3-BIS-AROMATISCHE-PROP-2-YN-1-ON

Title (fr)

1,3-BIS-AROMATIQUE-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIQUE-PROPANE-1-ONES ET 1,3-BIS-AROMATIQUE-PROP-2-YN-1-ONES A ACTION BIOLOGIQUE

Publication

EP 0996432 A2 (EN)

Application

EP 98929241 A

Priority

  • DK 9800283 W
  • DK 76297 A

Abstract (en)

[origin: WO9900114A2] The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatment or prophylaxis of a number of serious diseases including i) conditions relating to harmful effects of inflammatory cytokines, ii) conditions involving infection by Helicobacter species, iii) conditions involving infections by viruses, iv) neoplastic disorders, and v) conditions caused by microorganisms or parasites. The invention also relates to novel chalcones and dihydrochalcones (especially alkoxy substituted variants) having advantageous substitution patterns with respect to their effect as drug substances, and methods of preparing them, as well as to pharmaceutical compositions comprising the novel chalcones. Moreover, the present invention relates to a method for the isolation of Leishmania fumarate reductase, QSAR methodologies for selecting potent compounds for the above-mentioned purposes.

IPC 1-7 (main, further and additional classification)

A61K 31/12; A61K 31/135; A61K 31/275; C07C 49/84; C07C 205/45; C07C 225/22; C07C 255/56

IPC 8 full level (invention and additional information)

A61K 31/12 (2006.01); A61K 31/136 (2006.01); A61K 31/277 (2006.01); C07C 45/00 (2006.01); C07C 45/41 (2006.01); C07C 45/45 (2006.01); C07C 45/67 (2006.01); C07C 45/74 (2006.01); C07C 49/813 (2006.01); C07C 49/84 (2006.01); C07C 205/45 (2006.01); C07C 217/22 (2006.01); C07C 217/36 (2006.01); C07C 225/16 (2006.01); C07C 225/22 (2006.01); C07C 233/33 (2006.01); C07C 255/40 (2006.01)

CPC (invention and additional information)

C07C 255/40 (2013.01); A61K 31/12 (2013.01); A61K 31/136 (2013.01); A61K 31/277 (2013.01); C07C 45/00 (2013.01); C07C 45/41 (2013.01); C07C 45/455 (2013.01); C07C 45/67 (2013.01); C07C 45/673 (2013.01); C07C 45/74 (2013.01); C07C 49/813 (2013.01); C07C 49/84 (2013.01); C07C 205/45 (2013.01); C07C 217/22 (2013.01); C07C 217/36 (2013.01); C07C 225/16 (2013.01); C07C 225/22 (2013.01); C07C 233/33 (2013.01)

Combination set (CPC)

  1. C07C 45/00 + C07C 47/565
  2. C07C 45/41 + C07C 47/575
  3. C07C 45/455 + C07C 49/84
  4. C07C 45/67 + C07C 49/84
  5. C07C 45/673 + C07C 49/84
  6. C07C 45/74 + C07C 49/813
  7. C07C 45/74 + C07C 49/84

Citation (search report)

See references of WO 9900114A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB IT LI NL SE

EPO simple patent family

WO 9900114 A2 19990107; WO 9900114 A3 19990812; AU 7908098 A 19990119; EP 0996432 A2 20000503

INPADOC legal status

2003-08-27 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20030707

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61K 31/12 A

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61K 31/135 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61K 31/275 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7C 07C 49/84 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7C 07C 205/45 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7C 07C 225/22 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7C 07C 255/56 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61P 29/00 B

2003-08-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61P 33/02 B

2001-07-11 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010525

2001-03-28 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: LICA PHARMACEUTICALS A/S

- Ref Legal Event Code: RAP1

2000-05-10 [R17P] REQUEST FOR EXAMINATION FILED (CORRECTION)

- Ref Legal Event Code: R17P

- Effective date: 20000214

2000-05-03 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000214

2000-05-03 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB IT LI NL SE