Global patent index - EP 0996637 A1

EP 0996637 A1 2000-05-03 - RECOMBINANT PROTEIN C AND PROTEIN S VARIANTS

Title (en)

RECOMBINANT PROTEIN C AND PROTEIN S VARIANTS

Title (de)

REKOMBINANTE VARIANTEN VON PROTEIN C UND PROTEIN S

Title (fr)

VARIANTES DE PROTEINE C ET PROTEINE S RECOMBINANTES

Publication

EP 0996637 A1 (EN)

Application

EP 98915077 A

Priority

  • SE 9800490 W
  • SE 9701228 A

Abstract (en)

[origin: WO9844000A1] The present invention is concerned with a variant blood coagulation component, which is substantially homologous in amino acid sequence to wild-type blood coagulation component capable of expressing anticoagulant activity in the protein C-anticoagulant system of blood and selected from protein C (PC), activated protein C (APC) and protein S (PS), said variant component being capable of expressing an anticoagulant activity, which is enhanced in comparison with the anticoagulant activity expressed by the corresponding wild-type blood coagulation component, and said variant component differing from the respective wild-type component, in that it contains in comparison with the said wild-type component at least one amino acid residue modification in its amino acid residue sequence. The present invention is also concerned with methods to produce such variants based on DNA technology, DNA segments intended for use in the said methods, and the use of the said variants for therapeutic and diagnostic purposes.

IPC 1-7 (main, further and additional classification)

C07K 14/745; A61K 38/36; C12N 9/64; G01N 33/86

IPC 8 full level (invention and additional information)

A61K 38/36 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); C07K 14/745 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/86 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 9/6464 (2013.01); C12Y 304/21069 (2013.01); G01N 33/86 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9844000A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9844000 A1 19981008; AU 6934598 A 19981022; AU 741798 B2 20011213; CA 2283934 A1 19981008; EP 0996637 A1 20000503; JP 2002501373 A 20020115; NZ 337800 A 20010330; SE 9701228 D0 19970403

INPADOC legal status

2004-11-10 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20040920

2001-03-28 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010212

2000-05-03 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990908

2000-05-03 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE