EP 0996637 A1 20000503 - RECOMBINANT PROTEIN C AND PROTEIN S VARIANTS
Title (en)
RECOMBINANT PROTEIN C AND PROTEIN S VARIANTS
Title (de)
REKOMBINANTE VARIANTEN VON PROTEIN C UND PROTEIN S
Title (fr)
VARIANTES DE PROTEINE C ET PROTEINE S RECOMBINANTES
Publication
Application
Priority
- SE 9800490 W 19980318
- SE 9701228 A 19970403
Abstract (en)
[origin: WO9844000A1] The present invention is concerned with a variant blood coagulation component, which is substantially homologous in amino acid sequence to wild-type blood coagulation component capable of expressing anticoagulant activity in the protein C-anticoagulant system of blood and selected from protein C (PC), activated protein C (APC) and protein S (PS), said variant component being capable of expressing an anticoagulant activity, which is enhanced in comparison with the anticoagulant activity expressed by the corresponding wild-type blood coagulation component, and said variant component differing from the respective wild-type component, in that it contains in comparison with the said wild-type component at least one amino acid residue modification in its amino acid residue sequence. The present invention is also concerned with methods to produce such variants based on DNA technology, DNA segments intended for use in the said methods, and the use of the said variants for therapeutic and diagnostic purposes.
IPC 1-7
IPC 8 full level
A61K 38/36 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); C07K 14/745 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/86 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 9/10 (2017.12); C12N 9/6464 (2013.01); C12Y 304/21069 (2013.01); G01N 33/86 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9844000A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9844000 A1 19981008; AU 6934598 A 19981022; AU 741798 B2 20011213; CA 2283934 A1 19981008; EP 0996637 A1 20000503; JP 2002501373 A 20020115; NZ 337800 A 20010330; SE 9701228 D0 19970403
DOCDB simple family (application)
SE 9800490 W 19980318; AU 6934598 A 19980318; CA 2283934 A 19980318; EP 98915077 A 19980318; JP 54152998 A 19980318; NZ 33780098 A 19980318; SE 9701228 A 19970403