Global Patent Index - EP 0998560 A1

EP 0998560 A1 2000-05-10 - MODIFIED LEPIDOPTERAN RECEPTORS AND HYBRID MULTIFUNCTIONAL PROTEINS FOR USE IN REGULATION OF TRANSGENE EXPRESSION

Title (en)

MODIFIED LEPIDOPTERAN RECEPTORS AND HYBRID MULTIFUNCTIONAL PROTEINS FOR USE IN REGULATION OF TRANSGENE EXPRESSION

Title (de)

MODIFIZIERTE LEPIDOPTERA-REZEPTOREN UND HYBRIDE, MULTIFUNKTIONELLE PROTEINE ZUR REGULATION DER EXPRESSION VON TRANSGENEN

Title (fr)

PROTEINES MULTIFONCTIONNELLES HYBRIDES ET RECEPTEURS DE LEPIDOPTERANE MODIFIES DESTINES A ETRE UTILISES POUR REGULER L'EXPRESSION TRANSGENIQUE

Publication

EP 0998560 A1 (EN)

Application

EP 98934353 A

Priority

  • US 9814215 W
  • US 89129897 A
  • US 9187498 P

Abstract (en)

[origin: WO9902683A1] In accordance with the present invention, it has been discovered that nuclear receptor proteins isolated from the silk moth bombyx mori (bR) are useful for the regulation of transgene expression. bR is generally thought to be a strong transcriptional regulator within cells of the silk moth. In accordance with the present invention, it has been discovered that bR is also functional in mammalian cells. It has further been discovered that the addition of activation domains to the bR open-reading frame enhances the activity of the ligand modulated regulator to afford high-level transcriptional induction. Further modifications to the bR ligand binding domain result in receptors with unique tranactivational characteristics.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A01K 67/027; A61K 48/00; C07K 14/72; C12N 5/10; C12N 15/86; G01N 33/566

IPC 8 full level (invention and additional information)

C07K 14/72 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)

CPC (invention and additional information)

C07K 14/721 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2799/027 (2013.01)

Citation (search report)

See references of WO 9902683A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9902683 A1 19990121; AU 738494 B2 20010920; AU 8389598 A 19990208; CA 2296093 A1 19990121; EP 0998560 A1 20000510

INPADOC legal status


2003-12-03 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20031008

2003-08-06 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030624

2000-05-10 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000210

2000-05-10 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE