EP 0998560 A1 20000510 - MODIFIED LEPIDOPTERAN RECEPTORS AND HYBRID MULTIFUNCTIONAL PROTEINS FOR USE IN REGULATION OF TRANSGENE EXPRESSION
Title (en)
MODIFIED LEPIDOPTERAN RECEPTORS AND HYBRID MULTIFUNCTIONAL PROTEINS FOR USE IN REGULATION OF TRANSGENE EXPRESSION
Title (de)
MODIFIZIERTE LEPIDOPTERA-REZEPTOREN UND HYBRIDE, MULTIFUNKTIONELLE PROTEINE ZUR REGULATION DER EXPRESSION VON TRANSGENEN
Title (fr)
PROTEINES MULTIFONCTIONNELLES HYBRIDES ET RECEPTEURS DE LEPIDOPTERANE MODIFIES DESTINES A ETRE UTILISES POUR REGULER L'EXPRESSION TRANSGENIQUE
Publication
Application
Priority
- US 9814215 W 19980710
- US 89129897 A 19970710
- US 9187498 P 19980707
Abstract (en)
[origin: WO9902683A1] In accordance with the present invention, it has been discovered that nuclear receptor proteins isolated from the silk moth bombyx mori (bR) are useful for the regulation of transgene expression. bR is generally thought to be a strong transcriptional regulator within cells of the silk moth. In accordance with the present invention, it has been discovered that bR is also functional in mammalian cells. It has further been discovered that the addition of activation domains to the bR open-reading frame enhances the activity of the ligand modulated regulator to afford high-level transcriptional induction. Further modifications to the bR ligand binding domain result in receptors with unique tranactivational characteristics.
IPC 1-7
C12N 15/12; C12N 15/86; C12N 5/10; A01K 67/027; C07K 14/72; A61K 48/00; G01N 33/566
IPC 8 full level
C07K 14/72 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
C07K 14/721 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2799/027 (2013.01)
Citation (search report)
See references of WO 9902683A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9902683 A1 19990121; AU 738494 B2 20010920; AU 8389598 A 19990208; CA 2296093 A1 19990121; EP 0998560 A1 20000510
DOCDB simple family (application)
US 9814215 W 19980710; AU 8389598 A 19980710; CA 2296093 A 19980710; EP 98934353 A 19980710