Global Patent Index - EP 0999827 A1

EP 0999827 A1 2000-05-17 - NOVEL LIPOSOME VECTORS OF ACTIVE PRINCIPLES

Title (en)

NOVEL LIPOSOME VECTORS OF ACTIVE PRINCIPLES

Title (de)

NEUE LIPOSOMALE VEKTOREN FÜR WIRKSTOFFE

Title (fr)

NOUVEAUX VECTEURS LIPOSOMAUX DE PRINCIPES ACTIFS

Publication

EP 0999827 A1 (FR)

Application

EP 98930820 A

Priority

  • FR 9801204 W
  • FR 9707255 A

Abstract (en)

[origin: FR2764508A1] The invention concerns liposome vectors, in powder form, of active principles, and more particularly active principles sensitive to digestive and/or plasmatic degradation, such as proteins, and their application as medicine. Said liposome vectors of active principles consist of a powder composition essentially constituted of unilamellar liposomes comprising an external lipid phase consisting of class 4 lipids (phospholipids), optionally associated with class 2 substances, class 3 substances and/or class 5 substances and an internal aqueous nucleus consisting of a mixture M of at least two different non-polymerisable gelling agents (G1 and G2) whereof the gel-sol phase transition is not less than 37 DEG C, G1 being selected among gelatines and carrageenans and G2 being selected among carrageenans with properties different from the carrageenans selected for G1, and celluloses, which liposomes have a diameter ranging between 20 nm and 1 mm, preferably between 20 nm and 500 nm; said composition having the form of particulate units with an average particle diameter between 10 mm and 1000 mm, formed by one or several of said liposomes, enclosed in a sheath selected in the group consisting of a dehydrated thermoreversible aqueous gel identical to said internal nucleus aqueous gel, dextrins or a mixture thereof, such that they contain, on an average, 10<16> to 10<18> liposomes per gram of powder; and at least an active principle contained, as the case may be, either in the gelled internal nucleus or in the external lipid phase.

IPC 1-7 (main, further and additional classification)

A61K 9/127

IPC 8 full level (invention and additional information)

A61K 9/127 (2006.01); A61K 9/133 (2006.01)

CPC (invention and additional information)

A61K 9/127 (2013.01); A61K 9/1277 (2013.01); Y10S 514/824 (2013.01); Y10T 428/2984 (2013.01)

Citation (search report)

See references of WO 9856352A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2764508 A1 19981218; FR 2764508 B1 20001020; AU 738809 B2 20010927; AU 738809 C 20021024; AU 8112398 A 19981230; BR 9810258 A 20000919; CN 1264297 A 20000823; EP 0999827 A1 20000517; HU 0002069 A2 20001228; HU 0002069 A3 20010129; JP 2002511078 A 20020409; KR 20010013665 A 20010226; NZ 501795 A 20011130; PL 337757 A1 20000911; RU 2203649 C2 20030510; US 2002146447 A1 20021010; US 6656497 B2 20031202; WO 9856352 A1 19981217

INPADOC legal status


2005-04-27 [18W] WITHDRAWN

- Effective date: 20050228

2000-05-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000107

2000-05-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE