Global Patent Index - EP 1000036 A1

EP 1000036 A1 2000-05-17 - HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE

Title (en)

HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE

Title (de)

HYDANTOINDERIVATE MIT FARNESYLTRANSFERASE HEMMENDER AKTIVITÄT

Title (fr)

DERIVES D'HYDANTOINE DOTES D'UNE ACTIVITE INHIBITRICE VIS A VIS DE LA FARNESYLE TRANSFERASE

Publication

EP 1000036 A1 (EN)

Application

EP 98935376 A

Priority

  • KR 9800225 W
  • KR 19970035333 A

Abstract (en)

[origin: WO9905117A1] The present invention relates to novel hydantoin derivatives represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are defined as described below. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.

IPC 1-7 (main, further and additional classification)

C07D 233/76; A61K 31/415; C07D 401/06

IPC 8 full level (invention and additional information)

C07D 233/74 (2006.01); A61K 31/4178 (2006.01); A61K 31/427 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5355 (2006.01); A61K 31/541 (2006.01); A61P 35/00 (2006.01); C07D 233/76 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01)

CPC (invention and additional information)

C07D 401/14 (2013.01); C07D 233/76 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01)

Citation (search report)

See references of WO 9905117A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9905117 A1 19990204; AR 015412 A1 20010502; AU 729341 B2 20010201; AU 8464798 A 19990216; EP 1000036 A1 20000517; JP 2001510829 A 20010807; KR 100384116 B1 20030501; ZA 9806623 B 19990126

INPADOC legal status


2003-10-22 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030417

2001-03-14 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010126

2000-05-17 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000118

2000-05-17 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE