Global Patent Index - EP 1000044 A1

EP 1000044 A1 2000-05-17 - BENZOTHIA(OXA)DIAZOL DERIVATIVES AND THEIR USE AS ENDOTHELIN-RECEPTOR ANTAGONISTS

Title (en)

BENZOTHIA(OXA)DIAZOL DERIVATIVES AND THEIR USE AS ENDOTHELIN-RECEPTOR ANTAGONISTS

Title (de)

BENZOTHIA(OXA)DIAZOLDERIVATE UND IHRE VERWENDUNG ALS ENDOTHELIN-REZEPTOR-ANTAGONISTEN

Title (fr)

DERIVES DE BENZOTHIA(OXA)DIAZOL ET LEUR UTILISATION COMME ANTAGONISTES DES RECEPTEURS DE L'ENDOTHELINE

Publication

EP 1000044 A1 (DE)

Application

EP 98939552 A

Priority

  • DE 19731571 A
  • EP 9803957 W

Abstract (en)

[origin: DE19731571A1] The invention relates to novel compounds of formula (I), wherein R represents group (1), X stands for O or S, and R1, R2, R3, R4, R5 and R6 have the meaning cited in Claim 1, or a tauomeric cyclized form. The invention further relates to (E) isomers and their salts. Said novel derivatives exhibit endothelin-receptor antagonistic properties.

IPC 1-7 (main, further and additional classification)

C07D 285/14; A61K 31/41; C07D 271/12; C07D 413/04; C07D 417/04

IPC 8 full level (invention and additional information)

A61K 31/4245 (2006.01); A61K 31/433 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/06 (2006.01); A61P 13/08 (2006.01); A61P 13/12 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 271/12 (2006.01); C07D 285/14 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01)

CPC (invention and additional information)

C07D 285/14 (2013.01); C07D 271/12 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01)

Citation (search report)

See references of WO 9905132A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

DE 19731571 A1 19990128; AR 010933 A1 20000712; AU 733338 B2 20010510; AU 8802298 A 19990216; BR 9811537 A 20000829; CA 2297315 A1 19990204; CN 1265102 A 20000830; EP 1000044 A1 20000517; HU 0003335 A2 20010730; ID 22978 A 19991223; JP 2001510836 A 20010807; NO 20000324 A 20000121; NO 20000324 D0 20000121; PL 338070 A1 20000925; SK 512000 A3 20000711; TW 461887 B 20011101; US 6197800 B1 20010306; WO 9905132 A1 19990204; ZA 9806551 B 19990920

INPADOC legal status


2002-01-16 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20011121

2002-01-02 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20011109

2000-05-17 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991202

2000-05-17 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-05-17 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: LT PAYMENT 19991202;LV PAYMENT 19991202;RO PAYMENT 19991202;SI PAYMENT 19991202