EP 1000045 A1 20000517 - 1,4-DISUBSTITUTED PIPERAZINES
Title (en)
1,4-DISUBSTITUTED PIPERAZINES
Title (de)
1,4-DISUBSTITUIERTE PIPERAZINE
Title (fr)
PIPERAZINES 1,4-DISUBSTITUEES
Publication
Application
Priority
- EP 9804796 W 19980731
- IT MI971862 A 19970801
- IT MI971863 A 19970801
Abstract (en)
[origin: WO9906382A1] Compounds of formula (I) (n = 1 or 2, Het = monocyclic heteroaryl, R = cycloalkyl or monocyclic heteroaryl, R3 = H or lower alkyl, Z = bond, -CH2-, -CH2CH2-, -CH2C(O)-, -CH2CH(OH)-, -O-, -OCH2- or -C(O)-, B = substituted or unsubstituted aryl or heteroaryl) bind to 5HT1A receptors and are therefore useful for the treatment of neuromuscular dysfunctions of the lower urinary tract. The compounds in which Z = bond, B = a substituted phenyl group of formula (a) (R1 = H, halogen, alkoxy, NO2, NH2, NH(acyl), NHSO2(alkyl), R2 = halogen, alkoxy, polyfluoroalkoxy, CN, CONH2; provided that if R1 NH(acyl) or NHSO2(alkyl) then R2 = polyfluoroalkoxy) and the compounds in which Z = -CH2-, -CH2CH2-, -CH2C(O)-, -CH2CH(OH)-, -O-, -OCH2- or -C(O)- are claimed per se; other compounds are claimed for use in preparation of medicaments for treating neuromuscular dysfunctions of the lower urinary tract.
IPC 1-7
IPC 8 full level
A61K 31/495 (2006.01); A61P 13/10 (2006.01); A61P 43/00 (2006.01); C07D 213/75 (2006.01)
CPC (source: EP)
A61P 13/10 (2017.12); A61P 43/00 (2017.12); C07D 213/75 (2013.01)
Citation (search report)
See references of WO 9906382A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9906382 A1 19990211; AU 9256498 A 19990222; EP 1000045 A1 20000517; JP 2001512110 A 20010821
DOCDB simple family (application)
EP 9804796 W 19980731; AU 9256498 A 19980731; EP 98945130 A 19980731; JP 2000505141 A 19980731