Global Patent Index - EP 1000045 A1

EP 1000045 A1 2000-05-17 - 1,4-DISUBSTITUTED PIPERAZINES

Title (en)

1,4-DISUBSTITUTED PIPERAZINES

Title (de)

1,4-DISUBSTITUIERTE PIPERAZINE

Title (fr)

PIPERAZINES 1,4-DISUBSTITUEES

Publication

EP 1000045 A1 (EN)

Application

EP 98945130 A

Priority

  • EP 9804796 W
  • IT MI971862 A
  • IT MI971863 A

Abstract (en)

[origin: WO9906382A1] Compounds of formula (I) (n = 1 or 2, Het = monocyclic heteroaryl, R = cycloalkyl or monocyclic heteroaryl, R3 = H or lower alkyl, Z = bond, -CH2-, -CH2CH2-, -CH2C(O)-, -CH2CH(OH)-, -O-, -OCH2- or -C(O)-, B = substituted or unsubstituted aryl or heteroaryl) bind to 5HT1A receptors and are therefore useful for the treatment of neuromuscular dysfunctions of the lower urinary tract. The compounds in which Z = bond, B = a substituted phenyl group of formula (a) (R1 = H, halogen, alkoxy, NO2, NH2, NH(acyl), NHSO2(alkyl), R2 = halogen, alkoxy, polyfluoroalkoxy, CN, CONH2; provided that if R1 NH(acyl) or NHSO2(alkyl) then R2 = polyfluoroalkoxy) and the compounds in which Z = -CH2-, -CH2CH2-, -CH2C(O)-, -CH2CH(OH)-, -O-, -OCH2- or -C(O)- are claimed per se; other compounds are claimed for use in preparation of medicaments for treating neuromuscular dysfunctions of the lower urinary tract.

IPC 1-7 (main, further and additional classification)

C07D 295/10; A61K 31/495

IPC 8 full level (invention and additional information)

A61K 31/495 (2006.01); A61P 13/10 (2006.01); A61P 43/00 (2006.01); C07D 213/75 (2006.01)

CPC (invention and additional information)

C07D 213/75 (2013.01)

Citation (search report)

See references of WO 9906382A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906382 A1 19990211; AU 9256498 A 19990222; EP 1000045 A1 20000517; JP 2001512110 A 20010821

INPADOC legal status


2003-10-29 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030423

2002-07-24 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020610

2000-05-17 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000221

2000-05-17 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-05-17 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000221;LT PAYMENT 20000221;LV PAYMENT 20000221;MK PAYMENT 20000221;RO PAYMENT 20000221;SI PAYMENT 20000221