Global Patent Index - EP 1000054 A1

EP 1000054 A1 20000517 - OLIGO-THIOPHENES USEFUL AS ANTIMETASTATIC AGENTS, A PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (en)

OLIGO-THIOPHENES USEFUL AS ANTIMETASTATIC AGENTS, A PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (de)

OLIGOTHIOPHENE ALS ANTIMETASTASE-MITTEL, VERFAHREN ZUR HERSTELLUNG DAVON UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN

Title (fr)

OLIGO-THIOPHENES UTILES COMME AGENTS ANTIMETASTATIQUES, PREPARATION DE CES OLIGO-THIOPHENES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Publication

EP 1000054 A1 (EN)

Application

EP 98939643 A

Priority

  • EP 98939643 A
  • EP 9804705 W
  • EP 97113191 A

Abstract (en)

[origin: WO9906393A1] Oligo-thiophenes of formula (I) are disclosed wherein: A is a -CH2-CO-, -CH2CH2-CO- or -CH=CH-CO- group; B is a 2-thienyl or a phenyl group, which is substituted by an R group, or it is a natural or synthetic amino acid, linked to the A group via its N-terminus; or A-B is a -CH2CH2-NH-A.A.- group, wherein the A.A.-group is a natural or synthetic amino acid residue, linked to the CH2CH2-NH-group via its carboxy-terminus; R is hydrogen or a chlorine, bromine, iodine, fluorine, (C1-C4)alkyle, (C1-C4)alkylene- COOR', (C1-C4)alkylene-NH2, (C1-C4)alkylene-NR'2 or (C1-C4)alkylene-NHCOR' group; R' is hydrogen or a (C1-C4)alkyl group, isomers thereof, and salts thereof with pharmaceutically acceptable acids and bases. It is also claimed the use of the compounds of formula (I) as inhibitors of the uPA binding to the specific uPAR receptor, in particular their application as antitumor and antimetastatic agents.

IPC 1-7

C07D 333/24; C07D 409/14; A61K 31/38; A61K 31/405

IPC 8 full level

C07D 333/22 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01); A61K 31/405 (2006.01); A61P 35/00 (2006.01); C07D 333/24 (2006.01); C07D 409/14 (2006.01)

CPC (source: EP)

A61P 35/00 (2018.01); C07D 333/24 (2013.01); C07D 409/14 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9906393 A1 19990211; AR 020308 A1 20020508; AU 738104 B2 20010906; AU 8807998 A 19990222; BR 9811577 A 20000829; CA 2299045 A1 19990211; CN 1269797 A 20001011; CO 4970718 A1 20001107; EP 1000054 A1 20000517; HR P980420 A2 19990430; JP 2001512116 A 20010821; KR 20010022500 A 20010315; MA 26527 A1 20041220; TR 200000266 T2 20000921; ZA 9806800 B 20000131

DOCDB simple family (application)

EP 9804705 W 19980728; AR P980103754 A 19980730; AU 8807998 A 19980728; BR 9811577 A 19980728; CA 2299045 A 19980728; CN 98807766 A 19980728; CO 98043237 A 19980729; EP 98939643 A 19980728; HR P980420 A 19980730; JP 2000505151 A 19980728; KR 20007001086 A 20000131; MA 25199 A 19980731; TR 200000266 T 19980728; ZA 9806800 A 19980730