Global Patent Index - EP 1000054 A1

EP 1000054 A1 2000-05-17 - OLIGO-THIOPHENES USEFUL AS ANTIMETASTATIC AGENTS, A PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (en)

OLIGO-THIOPHENES USEFUL AS ANTIMETASTATIC AGENTS, A PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (de)

OLIGOTHIOPHENE ALS ANTIMETASTASE-MITTEL, VERFAHREN ZUR HERSTELLUNG DAVON UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN

Title (fr)

OLIGO-THIOPHENES UTILES COMME AGENTS ANTIMETASTATIQUES, PREPARATION DE CES OLIGO-THIOPHENES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Publication

EP 1000054 A1 (EN)

Application

EP 98939643 A

Priority

  • EP 98939643 A
  • EP 9804705 W
  • EP 97113191 A

Abstract (en)

[origin: WO9906393A1] Oligo-thiophenes of formula (I) are disclosed wherein: A is a -CH2-CO-, -CH2CH2-CO- or -CH=CH-CO- group; B is a 2-thienyl or a phenyl group, which is substituted by an R group, or it is a natural or synthetic amino acid, linked to the A group via its N-terminus; or A-B is a -CH2CH2-NH-A.A.- group, wherein the A.A.-group is a natural or synthetic amino acid residue, linked to the CH2CH2-NH-group via its carboxy-terminus; R is hydrogen or a chlorine, bromine, iodine, fluorine, (C1-C4)alkyle, (C1-C4)alkylene- COOR', (C1-C4)alkylene-NH2, (C1-C4)alkylene-NR'2 or (C1-C4)alkylene-NHCOR' group; R' is hydrogen or a (C1-C4)alkyl group, isomers thereof, and salts thereof with pharmaceutically acceptable acids and bases. It is also claimed the use of the compounds of formula (I) as inhibitors of the uPA binding to the specific uPAR receptor, in particular their application as antitumor and antimetastatic agents.

IPC 1-7 (main, further and additional classification)

C07D 333/24; A61K 31/38; A61K 31/405; C07D 409/14

IPC 8 full level (invention and additional information)

C07D 333/22 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01); A61K 31/405 (2006.01); A61P 35/00 (2006.01); C07D 333/24 (2006.01); C07D 409/14 (2006.01)

CPC (invention and additional information)

C07D 409/14 (2013.01); C07D 333/24 (2013.01)

Citation (search report)

See references of WO 9906393A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906393 A1 19990211; AR 020308 A1 20020508; AU 738104 B2 20010906; AU 8807998 A 19990222; BR 9811577 A 20000829; CA 2299045 A1 19990211; CN 1269797 A 20001011; CO 4970718 A1 20001107; EP 1000054 A1 20000517; HR P980420 A2 19990430; JP 2001512116 A 20010821; MA 26527 A1 20041220; TR 200000266 T2 20000921; ZA 9806800 B 20000131

INPADOC legal status


2003-10-08 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030401

2000-05-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000229

2000-05-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-05-17 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000229;LT PAYMENT 20000229;LV PAYMENT 20000229;MK PAYMENT 20000229;RO PAYMENT 20000229;SI PAYMENT 20000229