EP 1000076 A1 20000517 - HEXADECASACCHARIDE-PROTEIN CONJUGATE VACCINE FOR $i(SHIGELLA DYSENTERIAE) TYPE 1
Title (en)
HEXADECASACCHARIDE-PROTEIN CONJUGATE VACCINE FOR $i(SHIGELLA DYSENTERIAE) TYPE 1
Title (de)
IMPFSTOFF GEGEN SHIGELLA DYSENTERIAE 1 AUF BASIS EINES HEXADECASACCHARIDPROTEINKONJUGATES
Title (fr)
VACCIN CONJUGUE HEXADECASACCHARIDE-PROTEINE CONTRE $i(SHIGELLA DYSENTERIAE) DE TYPE 1
Publication
Application
Priority
- US 9814698 W 19980715
- US 5286997 P 19970717
Abstract (en)
[origin: WO9903871A1] The present invention pertains to isolated natural, modified natural or synthetic oligo- or polysaccharides which have [3)- alpha -L-Rhap-(1}2)- alpha -D-Galp-(1}3)- alpha -D-GlcpNAc-(1}3)- alpha -L-Rhap-(1}]n subunits and which are structurally related to and/or antigenically similar to an antigenic determinant of the O-specific polysaccharide of Shigella dysenteriae type 1. The oligo- or polysaccharides may be conjugated to a carrier to form conjugates. These oligo- or polysaccharides and conjugates thereof are immunogenic and elicit serum antibodies that are bactericidal or bacteriostatic against Shigella dysenteriae, in particular Shigella dysenteriae type 1, and are useful in the prevention and treatment of shigellosis. These oligo- or polysaccharides and conjugates thereof, and the antibodies which they elicit, are also useful for diagnosing shigellosis caused by Shigella dysentariae type 1.
IPC 1-7
IPC 8 full level
A61K 39/02 (2006.01); A61K 39/112 (2006.01); A61K 47/48 (2006.01); C07H 5/06 (2006.01)
CPC (source: EP)
A61K 39/0283 (2013.01); A61K 47/646 (2017.07); A61K 2039/6037 (2013.01); A61K 2039/6081 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 9903871A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9903871 A1 19990128; AU 8407298 A 19990210; EP 1000076 A1 20000517
DOCDB simple family (application)
US 9814698 W 19980715; AU 8407298 A 19980715; EP 98934584 A 19980715