Global Patent Index - EP 1000076 A1

EP 1000076 A1 2000-05-17 - HEXADECASACCHARIDE-PROTEIN CONJUGATE VACCINE FOR $i(SHIGELLA DYSENTERIAE) TYPE 1

Title (en)

HEXADECASACCHARIDE-PROTEIN CONJUGATE VACCINE FOR $i(SHIGELLA DYSENTERIAE) TYPE 1

Title (de)

IMPFSTOFF GEGEN SHIGELLA DYSENTERIAE 1 AUF BASIS EINES HEXADECASACCHARIDPROTEINKONJUGATES

Title (fr)

VACCIN CONJUGUE HEXADECASACCHARIDE-PROTEINE CONTRE $i(SHIGELLA DYSENTERIAE) DE TYPE 1

Publication

EP 1000076 A1 (EN)

Application

EP 98934584 A

Priority

  • US 9814698 W
  • US 5286997 P

Abstract (en)

[origin: WO9903871A1] The present invention pertains to isolated natural, modified natural or synthetic oligo- or polysaccharides which have [3)- alpha -L-Rhap-(1}2)- alpha -D-Galp-(1}3)- alpha -D-GlcpNAc-(1}3)- alpha -L-Rhap-(1}]n subunits and which are structurally related to and/or antigenically similar to an antigenic determinant of the O-specific polysaccharide of Shigella dysenteriae type 1. The oligo- or polysaccharides may be conjugated to a carrier to form conjugates. These oligo- or polysaccharides and conjugates thereof are immunogenic and elicit serum antibodies that are bactericidal or bacteriostatic against Shigella dysenteriae, in particular Shigella dysenteriae type 1, and are useful in the prevention and treatment of shigellosis. These oligo- or polysaccharides and conjugates thereof, and the antibodies which they elicit, are also useful for diagnosing shigellosis caused by Shigella dysentariae type 1.

IPC 1-7 (main, further and additional classification)

C07H 15/04; A61K 39/00; C07K 16/12

IPC 8 full level (invention and additional information)

A61K 39/02 (2006.01); A61K 39/112 (2006.01); A61K 47/48 (2006.01); C07H 5/06 (2006.01)

CPC (invention and additional information)

A61K 47/4833 (2013.01); A61K 39/0283 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/6081 (2013.01)

Citation (search report)

See references of WO 9903871A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9903871 A1 19990128; AU 8407298 A 19990210; EP 1000076 A1 20000517

INPADOC legal status


2002-08-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020201

2000-05-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000114

2000-05-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE