EP 1000157 A1 20000517 - HOMOGENEOUS HUMAN PAPILLOMA VIRUS CAPSOMERE CONTAINING COMPOSITIONS, METHODS FOR MANUFACTURE, AND THE USE THEREOF AS DIAGNOSTIC, PROPHYLACTIC OR THERAPY

Title (en)

HOMOGENEOUS HUMAN PAPILLOMA VIRUS CAPSOMERE CONTAINING COMPOSITIONS, METHODS FOR MANUFACTURE, AND THE USE THEREOF AS DIAGNOSTIC, PROPHYLACTIC OR THERAPY

Title (de)

ZUSAMMENSETZUNGEN, DIE HOMOGENE KAPSOMERE DES MENSCHLICHEN PAPILLOMAVIRUS ENTHALTEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG IN DER DIAGNOSE, PROPHYLAXE UND THERAPIE

Title (fr)

COMPOSITIONS RENFERMANT DES CAPSOMERES DE PAPILLOMAVIRUS HUMAIN HOMOGENE, LEURS PROCEDES DE PRODUCTION ET LEURS PROCEDES D'UTILISATION EN TANT QU'AGENTS DIAGNOSTIQUES, PROPHYLACTIQUES OU THERAPEUTIQUES

Publication

EP 1000157 A1 20000517 (EN)

Application

EP 98933101 A 19980702

Priority

US 9813799 W 19980702
US 88805097 A 19970703

Abstract (en)

[origin: WO9901557A1] The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.

IPC 1-7

C12N 15/37; C07K 14/025; A61K 39/12; G01N 33/68

IPC 8 full level

G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61K 39/12 (2006.01); A61P 31/20 (2006.01); C07K 14/025 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/37 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP)

A61P 31/20 (2018.01); C07K 14/005 (2013.01); A61K 39/00 (2013.01); C12N 2710/20022 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9901557 A1 19990114; AU 755679 B2 20021219; AU 8284298 A 19990125; CA 2295316 A1 19990114; CA 2295316 C 20070626; EP 1000157 A1 20000517; JP 2002510976 A 20020409

DOCDB simple family (application)

US 9813799 W 19980702; AU 8284298 A 19980702; CA 2295316 A 19980702; EP 98933101 A 19980702; JP 50738299 A 19980702