EP 1000357 A1 20000517 - ANTIBODIES AND SCFV IMMUNOTOXINS SPECIFIC TO IMPORTED FIRE ANTS, AND THEIR APPLICATION
Title (en)
ANTIBODIES AND SCFV IMMUNOTOXINS SPECIFIC TO IMPORTED FIRE ANTS, AND THEIR APPLICATION
Title (de)
ANTIKÖRPER UND SCFV-IMMUNOTOXINE SPEZIFISCH FÜR IMPORTIERTE FEUERAMEISEN UND IHRE ANWENDUNG
Title (fr)
ANTICORPS ET IMMUNOTOXINES SCFV SPECIFIQUES DES FOURMIS DE FEU IMPORTEES, ET APPLICATION DE CES ANTICORPS ET IMMUNOTOXINES
Publication
Application
Priority
- US 9814216 W 19980709
- US 5213297 P 19970710
Abstract (en)
[origin: WO9902991A1] The present invention is drawn to a safe, cost-effective, environmentally-friendly and ecologically-sound bioengineered product for managing imported fire ants, and a method of making this product. Immunological and genetic engineering techniques are used to generate monoclonal antibodies (mAbs) as well as viruses (phage) that display scFv heavy and/or light chain Ig fragments which exhibit high-avidity specific binding to cells of the microvilli of the midgut of imported fire ant queens. The specific monoclonal antibodies and phage displayed antibody Fab fragments are conjugated to a toxin for targeted delivery and destruction of imported fire ant queens, but not native species, thereby restoring the natural ecosystem.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); A01N 61/00 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/44 (2006.01); C07K 19/00 (2006.01); C12N 5/18 (2006.01); C12N 15/02 (2006.01); C12N 15/09 (2006.01); C12P 21/00 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR)
C07K 16/00 (2013.01 - EP); C07K 16/18 (2013.01 - EP); G01N 33/53 (2013.01 - KR); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9902991 A1 19990121; AU 739004 B2 20011004; AU 8389698 A 19990208; CA 2295914 A1 19990121; CN 1148577 C 20040505; CN 1263598 A 20000816; EP 1000357 A1 20000517; EP 1000357 A4 20050525; IL 133666 A0 20010430; JP 2001509397 A 20010724; KR 20010021624 A 20010315; NZ 501963 A 20010831; RU 2002132957 A 20050127; RU 2208641 C2 20030720; TW 585921 B 20040501; ZA 986114 B 20000110
DOCDB simple family (application)
US 9814216 W 19980709; AU 8389698 A 19980709; CA 2295914 A 19980709; CN 98807079 A 19980709; EP 98934354 A 19980709; IL 13366698 A 19980709; JP 2000502422 A 19980709; KR 20007000182 A 20000108; NZ 50196398 A 19980709; RU 2000103044 A 19980709; RU 2002132957 A 20021206; TW 87109169 A 19980609; ZA 986114 A 19980710