Global Patent Index - EP 1001800 A2

EP 1001800 A2 2000-05-24 - BIOLOGICALLY ACTIVE PEPTIDES WITH REDUCED TOXICITY IN ANIMALS AND A METHOD FOR PREPARING SAME

Title (en)

BIOLOGICALLY ACTIVE PEPTIDES WITH REDUCED TOXICITY IN ANIMALS AND A METHOD FOR PREPARING SAME

Title (de)

BIOLOGISCH AKTIVE PEPTIDE MIT VERMINDERTER TOXIZITÄT IN TIEREN UND EIN VERFAHREN ZU DEREN HERSTELLUNG

Title (fr)

PEPTIDES BIOLOGIQUEMENT ACTIFS A TOXICITE REDUITE CHEZ L'ANIMAL ET PROCEDES D'ELABORATION

Publication

EP 1001800 A2 (EN)

Application

EP 98933343 A

Priority

  • US 9814610 W
  • US 89300697 A

Abstract (en)

[origin: WO9903488A2] The present invention relates to biologically active peptides with reduced toxicity and methods of preparing them. The peptides of the invention, which can be unsubstituted or N-terminal substituted have formula (I), wherein X is a biologically active amphiphilic ion channel-forming peptide or protein, T is a lipophilic moiety or hydrogen, and W is T or hydrogen. Preferably T is formula (II), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. The peptides and proteins of the invention have improved antimicrobial and anti-tumor biological activity while exhibiting reduced toxicity. A preferred method of reducing toxicity involves the formation of related methane sulfonate derivatives or analogues. Additionally, the compounds of the invention may be used to treat sepsis, septic shock, and lung infections, such as those occuring in cystic fibrosis.

IPC 1-7 (main, further and additional classification)

A61K 38/17; A61K 38/04; C07K 14/00; C07K 14/435; C07K 14/46

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); C07K 1/02 (2006.01); C07K 14/435 (2006.01); C07K 14/46 (2006.01); C07K 14/47 (2006.01)

CPC (invention and additional information)

C07K 14/46 (2013.01); C07K 14/43563 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9903488A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9903488 A2 19990128; WO 9903488 A3 19990408; AU 8300598 A 19990210; CA 2294518 A1 19990128; EP 1001800 A2 20000524; JP 2001510164 A 20010731

INPADOC legal status


2003-05-02 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030203

2002-06-19 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020507

2000-05-24 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000125

2000-05-24 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE