EP 1001940 A1 20000524 - CONDENSED PYRAZOLE COMPOUNDS
Title (en)
CONDENSED PYRAZOLE COMPOUNDS
Title (de)
CONDENSIERTE PYRAZOLVERBINDGUNGEN
Title (fr)
COMPOSES HETEROCYCLIQUES CONDENSES
Publication
Application
Priority
- EP 9804217 W 19980702
- GB 9716103 A 19970730
Abstract (en)
[origin: WO9906374A1] Use of a compound which is a condensed pyrazole derivative of formula (I) wherein W is -CONH-, -SO2- or -CO-; X is -O- or -NR4- in which R4 is hydrogen, C1-C6 alkyl, benzyl, pyridyl, tetrahydropyranyl or a phenyl ring, the phenyl ring being unsubstituted or substituted by one or two substituents which are the same or different and are chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R, R1, and R2, which are the same or different, is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino or C1-C6 alkoxy-carbonyl; and R3 is hydrogen, or R2 and R3 taken together form a C2-C6 alkylene, -CH=CH-CH= or -O-(CH2)n- chain in which n is 1, 2 or 3; m is zero or an integer of 1 to 6; and Q is C1-C14 alkyl, a phenyl ring or an unsaturated pentatomic heteromonocyclic ring containing two or three heteroatoms which are the same or different and are chosen independently from oxygen, sulphur and nitrogen, wherein the phenyl ring and the heteromonocyclic ring are unsubstituted or substituted by one or two substitutents which are the same or different and are chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use as a kynurenine-3-hydroxylase inhibitor.
IPC 1-7
C07D 231/54; A61K 31/415; A61K 31/42; C07D 261/20; C07D 491/06; C07D 498/06
IPC 8 full level
A61K 31/416 (2006.01); A61K 31/4162 (2006.01); A61K 31/42 (2006.01); A61K 31/423 (2006.01); A61K 31/424 (2006.01); A61P 25/08 (2006.01); A61P 43/00 (2006.01); C07D 231/54 (2006.01); C07D 261/20 (2006.01); C07D 491/06 (2006.01); C07D 498/06 (2006.01)
CPC (source: EP)
A61P 25/08 (2017.12); A61P 43/00 (2017.12); C07D 231/54 (2013.01); C07D 261/20 (2013.01); C07D 491/06 (2013.01)
Citation (search report)
See references of WO 9906374A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9906374 A1 19990211; AU 8806698 A 19990222; CA 2297096 A1 19990211; EP 1001940 A1 20000524; GB 9716103 D0 19971001; JP 2001512106 A 20010821
DOCDB simple family (application)
EP 9804217 W 19980702; AU 8806698 A 19980702; CA 2297096 A 19980702; EP 98939623 A 19980702; GB 9716103 A 19970730; JP 2000505133 A 19980702