Global Patent Index - EP 1001940 A1

EP 1001940 A1 2000-05-24 - CONDENSED PYRAZOLE COMPOUNDS

Title (en)

CONDENSED PYRAZOLE COMPOUNDS

Title (de)

CONDENSIERTE PYRAZOLVERBINDGUNGEN

Title (fr)

COMPOSES HETEROCYCLIQUES CONDENSES

Publication

EP 1001940 A1 (EN)

Application

EP 98939623 A

Priority

  • EP 9804217 W
  • GB 9716103 A

Abstract (en)

[origin: WO9906374A1] Use of a compound which is a condensed pyrazole derivative of formula (I) wherein W is -CONH-, -SO2- or -CO-; X is -O- or -NR4- in which R4 is hydrogen, C1-C6 alkyl, benzyl, pyridyl, tetrahydropyranyl or a phenyl ring, the phenyl ring being unsubstituted or substituted by one or two substituents which are the same or different and are chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R, R1, and R2, which are the same or different, is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino or C1-C6 alkoxy-carbonyl; and R3 is hydrogen, or R2 and R3 taken together form a C2-C6 alkylene, -CH=CH-CH= or -O-(CH2)n- chain in which n is 1, 2 or 3; m is zero or an integer of 1 to 6; and Q is C1-C14 alkyl, a phenyl ring or an unsaturated pentatomic heteromonocyclic ring containing two or three heteroatoms which are the same or different and are chosen independently from oxygen, sulphur and nitrogen, wherein the phenyl ring and the heteromonocyclic ring are unsubstituted or substituted by one or two substitutents which are the same or different and are chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use as a kynurenine-3-hydroxylase inhibitor.

IPC 1-7 (main, further and additional classification)

C07D 231/54; A61K 31/415; A61K 31/42; C07D 261/20; C07D 491/06; C07D 498/06

IPC 8 full level (invention and additional information)

A61K 31/416 (2006.01); A61K 31/4162 (2006.01); A61K 31/42 (2006.01); A61K 31/423 (2006.01); A61K 31/424 (2006.01); A61P 25/08 (2006.01); A61P 43/00 (2006.01); C07D 231/54 (2006.01); C07D 261/20 (2006.01); C07D 491/06 (2006.01); C07D 498/06 (2006.01)

CPC (invention and additional information)

C07D 231/54 (2013.01); C07D 261/20 (2013.01); C07D 491/06 (2013.01)

Citation (search report)

See references of WO 9906374A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906374 A1 19990211; AU 8806698 A 19990222; CA 2297096 A1 19990211; EP 1001940 A1 20000524; GB 9716103 D0 19971001; JP 2001512106 A 20010821

INPADOC legal status


2001-05-02 [18W] WITHDRAWN

- Date of withdrawal: 20010223

2000-08-30 [RIN1] INVENTOR (CORRECTION)

- Inventor name: VARASI, MARIO

2000-08-30 [RIN1] INVENTOR (CORRECTION)

- Inventor name: PEVARELLO, PAOLO

2000-08-30 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HEIDEMPERGHER, FRANCO

2000-08-30 [RIN1] INVENTOR (CORRECTION)

- Inventor name: TOMA, SALVATORE

2000-08-30 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SPECIALE, CARMELA

2000-05-24 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000126

2000-05-24 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE