Global Patent Index - EP 1001971 A1

EP 1001971 A1 2000-05-24 - DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (en)

DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (de)

DIPEPTIDE UND VERWANDTE VERBINDUNGEN, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN

Title (fr)

COMPOSES DE DIPEPTIDES ET ASSOCIES INHIBANT UNE ADHESION DE LEUCOCYTES REGULEE PAR VLA-4

Publication

EP 1001971 A1 (EN)

Application

EP 98937053 A

Priority

  • US 90441797 A
  • US 9815325 W

Abstract (en)

[origin: WO9906432A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brains diseases such as multiple sclerosis.

IPC 1-7 (main, further and additional classification)

C07K 5/062; A61K 38/05; C07K 5/078

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/072 (2006.01); C07K 5/078 (2006.01)

CPC (invention and additional information)

C07K 5/06026 (2013.01); C07K 5/06104 (2013.01); C07K 5/06139 (2013.01); C07K 5/06165 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9906432A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906432 A1 19990211; AU 8585098 A 19990222; BR 9812111 A 20000718; CA 2290749 A1 19990211; CN 1265670 A 20000906; EP 1001971 A1 20000524; HU 0002495 A2 20001228; HU 0002495 A3 20010129; IL 133639 D0 20010430; JP 2001512135 A 20010821; NO 20000410 A 20000328; NO 20000410 D0 20000127; PL 338373 A1 20001023

INPADOC legal status


2007-03-09 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Ref Legal Event Code: WD

- Ref Document Number: 1026216

- Country of Ref Document: HK

2003-08-13 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030201

2000-05-24 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000225

2000-05-24 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-05-24 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000225;LT PAYMENT 20000225;LV PAYMENT 20000225;MK PAYMENT 20000225;RO PAYMENT 20000225;SI PAYMENT 20000225