EP 1001971 A1 20000524 - DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (en)
DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (de)
DIPEPTIDE UND VERWANDTE VERBINDUNGEN, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN
Title (fr)
COMPOSES DE DIPEPTIDES ET ASSOCIES INHIBANT UNE ADHESION DE LEUCOCYTES REGULEE PAR VLA-4
Publication
Application
Priority
- US 90441797 A 19970731
- US 9815325 W 19980731
Abstract (en)
[origin: WO9906432A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brains diseases such as multiple sclerosis.
IPC 1-7
IPC 8 full level
A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61K 38/00 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/072 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP KR)
A61P 3/10 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/18 (2018.01 - EP); C07K 5/06017 (2013.01 - KR); C07K 5/06026 (2013.01 - EP); C07K 5/06104 (2013.01 - EP); C07K 5/06139 (2013.01 - EP); C07K 5/06165 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9906432 A1 19990211; AU 8585098 A 19990222; BR 9812111 A 20000718; CA 2290749 A1 19990211; CN 1265670 A 20000906; EP 1001971 A1 20000524; HU P0002495 A1 20001228; HU P0002495 A3 20010129; IL 133639 A0 20010430; JP 2001512135 A 20010821; KR 20010022406 A 20010315; NO 20000410 D0 20000127; NO 20000410 L 20000328; PL 338373 A1 20001023
DOCDB simple family (application)
US 9815325 W 19980731; AU 8585098 A 19980731; BR 9812111 A 19980731; CA 2290749 A 19980731; CN 98807807 A 19980731; EP 98937053 A 19980731; HU P0002495 A 19980731; IL 13363998 A 19980731; JP 2000505187 A 19980731; KR 20007000986 A 20000128; NO 20000410 A 20000127; PL 33837398 A 19980731