EP 1001972 A1 20000524 - SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (en)
SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (de)
SUBSTITUIERTE PHENYLALANIN-DERIVATE, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN
Title (fr)
COMPOSES DE TYPE PHENYLALANINE SUBSTITUEE INHIBANT UNE ADHESION DE LEUCOCYTES REGULEE PAR VLA-4
Publication
Application
Priority
- US 9815313 W 19980730
- US 92039497 A 19970731
Abstract (en)
[origin: WO9906431A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds are also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
IPC 1-7
IPC 8 full level
A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP KR)
A61P 9/10 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 5/06017 (2013.01 - KR); C07K 5/06026 (2013.01 - EP); C07K 5/0606 (2013.01 - EP); C07K 5/06078 (2013.01 - EP); C07K 5/06139 (2013.01 - EP); C07K 5/06165 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9906431 A1 19990211; AR 013384 A1 20001227; AU 756696 B2 20030123; AU 8661198 A 19990222; BR 9812114 A 20000718; CA 2290747 A1 19990211; CN 1133648 C 20040107; CN 1265668 A 20000906; EP 1001972 A1 20000524; HU P0004259 A2 20010428; HU P0004259 A3 20010528; IL 133640 A0 20010430; JP 2001512134 A 20010821; KR 20010022411 A 20010315; NO 20000450 D0 20000128; NO 20000450 L 20000328; NZ 502582 A 20020726; PL 338423 A1 20001106; TW 534910 B 20030601; ZA 986827 B 20000502
DOCDB simple family (application)
US 9815313 W 19980730; AR P980103778 A 19980730; AU 8661198 A 19980730; BR 9812114 A 19980730; CA 2290747 A 19980730; CN 98807753 A 19980730; EP 98937990 A 19980730; HU P0004259 A 19980730; IL 13364098 A 19980730; JP 2000505186 A 19980730; KR 20007000991 A 20000128; NO 20000450 A 20000128; NZ 50258298 A 19980730; PL 33842398 A 19980730; TW 87112638 A 19980731; ZA 986827 A 19980730