Global Patent Index - EP 1001973 A1

EP 1001973 A1 2000-05-24 - COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (en)

COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (de)

VERBINDUNGEN, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN

Title (fr)

COMPOSES INHIBANT L'ADHESION LEUCOCYTAIRE INDUITE PAR VLA-4

Publication

EP 1001973 A1 (EN)

Application

EP 98938207 A

Priority

  • US 9815952 W
  • US 90441697 A

Abstract (en)

[origin: WO9906433A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

IPC 1-7 (main, further and additional classification)

C07K 5/062; A61K 38/05; C07K 5/065; C07K 5/072; C07K 5/078

IPC 8 full level (invention and additional information)

C07D 333/20 (2006.01); A61K 31/381 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61K 31/428 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4439 (2006.01); A61K 31/472 (2006.01); A61K 38/00 (2006.01); A61P 1/00 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07D 209/20 (2006.01); C07D 213/55 (2006.01); C07D 217/26 (2006.01); C07D 277/80 (2006.01); C07D 417/14 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); C07K 5/072 (2006.01); C07K 5/078 (2006.01)

CPC (invention and additional information)

C07K 5/0606 (2013.01); C07K 5/06026 (2013.01); C07K 5/06078 (2013.01); C07K 5/06113 (2013.01); C07K 5/06139 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9906433A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906433 A1 19990211; AU 8678698 A 19990222; BR 9811569 A 20000919; CA 2290746 A1 19990211; CN 1265669 A 20000906; EP 1001973 A1 20000524; HU 0004529 A2 20010428; HU 0004529 A3 20010528; IL 133641 D0 20010430; JP 2001512136 A 20010821; NO 20000451 A 20000323; NO 20000451 D0 20000128; PL 338506 A1 20001106

INPADOC legal status


2007-03-09 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1026218

2003-08-13 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030201

2000-05-24 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000225

2000-05-24 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-05-24 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000225;LT PAYMENT 20000225;LV PAYMENT 20000225;MK PAYMENT 20000225;RO PAYMENT 20000225;SI PAYMENT 20000225