Global Patent Index - EP 1001975 A1

EP 1001975 A1 2000-05-24 - BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (en)

BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Title (de)

BENZYLVERBINDUNGEN, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN

Title (fr)

COMPOSES DE BENZYLE INHIBANT UNE ADHESION DE LEUCOCYTES REGULEE PAR VLA-4

Publication

EP 1001975 A1 (EN)

Application

EP 98937054 A

Priority

  • US 9815327 W
  • US 90358597 A

Abstract (en)

[origin: WO9906436A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, wherein the disease may be, for example, asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The coumpounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

IPC 1-7 (main, further and additional classification)

C07K 5/078; A61K 31/40; A61K 38/05; C07D 207/16

IPC 8 full level (invention and additional information)

C07D 277/20 (2006.01); A61K 31/401 (2006.01); A61K 31/426 (2006.01); A61K 38/00 (2006.01); A61P 11/06 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 207/48 (2006.01); C07D 277/56 (2006.01); C07K 5/078 (2006.01)

CPC (invention and additional information)

C07K 5/06165 (2013.01); C07K 5/06139 (2013.01)

Citation (search report)

See references of WO 9906436A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9906436 A1 19990211; AU 8585198 A 19990222; BR 9811573 A 20000919; CA 2291473 A1 19990211; CN 1265675 A 20000906; EP 1001975 A1 20000524; HU 0002680 A2 20010730; HU 0002680 A3 20011228; IL 133635 D0 20010430; JP 2001512138 A 20010821; NO 20000414 A 20000328; NO 20000414 D0 20000127; PL 338510 A1 20001106

INPADOC legal status


2007-03-09 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1026219

2002-07-10 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20011121

2001-08-22 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010710

2000-05-24 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000225

2000-05-24 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-05-24 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000225;LT PAYMENT 20000225;LV PAYMENT 20000225;MK PAYMENT 20000225;RO PAYMENT 20000225;SI PAYMENT 20000225