EP 1001975 A1 20000524 - BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (en)
BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (de)
BENZYLVERBINDUNGEN, DIE DIE VLA-4 VERMITTELTE ADHÄSION VON LEUKOZYTEN INHIBIEREN
Title (fr)
COMPOSES DE BENZYLE INHIBANT UNE ADHESION DE LEUCOCYTES REGULEE PAR VLA-4
Publication
Application
Priority
- US 9815327 W 19980731
- US 90358597 A 19970731
Abstract (en)
[origin: WO9906436A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, wherein the disease may be, for example, asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The coumpounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
IPC 1-7
IPC 8 full level
A61K 31/401 (2006.01); A61K 31/426 (2006.01); A61K 38/00 (2006.01); A61P 11/06 (2006.01); C07D 277/20 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 207/48 (2006.01); C07D 277/56 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP KR)
A61P 11/06 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 5/06139 (2013.01 - EP KR); C07K 5/06165 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9906436 A1 19990211; AU 8585198 A 19990222; BR 9811573 A 20000919; CA 2291473 A1 19990211; CN 1265675 A 20000906; EP 1001975 A1 20000524; HU P0002680 A2 20010730; HU P0002680 A3 20011228; IL 133635 A0 20010430; JP 2001512138 A 20010821; KR 20010022413 A 20010315; NO 20000414 D0 20000127; NO 20000414 L 20000328; PL 338510 A1 20001106
DOCDB simple family (application)
US 9815327 W 19980731; AU 8585198 A 19980731; BR 9811573 A 19980731; CA 2291473 A 19980731; CN 98807764 A 19980731; EP 98937054 A 19980731; HU P0002680 A 19980731; IL 13363598 A 19980731; JP 2000505191 A 19980731; KR 20007000993 A 20000128; NO 20000414 A 20000127; PL 33851098 A 19980731