EP 1002083 A1 20000524 - APROTININ VARIANTS WITH IMPROVED PROPERTIES AND BIKUNINS OF APROTININ VARIANTS
Title (en)
APROTININ VARIANTS WITH IMPROVED PROPERTIES AND BIKUNINS OF APROTININ VARIANTS
Title (de)
APROTININVARIANTEN MIT VERBESSERTEN EIGENSCHAFTEN UND BIKUNINE VON APROTININVARIANTEN
Title (fr)
VARIANTES D'APROTININE A PROPRIETES AMELIOREES ET BIKUNINES DE VARIANTES D'APROTININE
Publication
Application
Priority
- DE 19725014 A 19970613
- EP 9803259 W 19980602
Abstract (en)
[origin: DE19725014A1] The invention relates to aprotinin variants with a net charge of +3 to -3 at pH 7. In the binding site, the amino acid radical 10 is Ser, the amino acid radical 13 is Ile, Phe or Leu, the amino acid radical 15 is Arg, the amino acid radical 17 is Tyr, Leu or Arg, and the amino acid radical 19 is Thr or Lys. The invention also relates to bikunins, comprising two aprotinin variants linked by a spacer with several amino acid radicals. One of said aprotinin variants is a) an aprotinin variant wherein the amino acid radical 13 is Ile, Phe or Leu, the amino acid radical 15 is Arg, Val or Leu, the amino acid radical 17 is Tyr, Leu or Ala, the amino acid radical 19 is Thr or Lys, the amino acid radical 39 is Arg or Leu, and the amino acid radical 46 is Leu or Lys; or b) an inventive aprotinin variant as defined above. The invention also relates to medicaments containing one or several of said aprotinin variants or bikunins, DNA sequences which give the coding for one of said aprotinin variants or bikunins, micro-organisms containing a DNA sequence of this type, and a method for producing said aprotinin variants and bikunins using micro-organisms.
IPC 1-7
IPC 8 full level
A61K 38/55 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); A61P 41/00 (2006.01); C07K 14/81 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/15 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 9/10 (2017.12); A61P 41/00 (2017.12); C07K 14/8117 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9856916A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
DE 19725014 A1 19981217; AU 8108998 A 19981230; EP 1002083 A1 20000524; JP 2002503958 A 20020205; WO 9856916 A1 19981217
DOCDB simple family (application)
DE 19725014 A 19970613; AU 8108998 A 19980602; EP 9803259 W 19980602; EP 98930775 A 19980602; JP 50147199 A 19980602