EP 1002123 A1 20000524 - ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS
Title (en)
ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS
Title (de)
ENZYMATISCHE KINETISCHE HERSTELLUNG EINES ZWISCHENPRODUKTES FÜR DIE HERSTELLUNG VON SUBSTITUIERTEN TRICYCLISCHEN VERBINDUNGEN
Title (fr)
RESOLUTION CINETIQUE ENZYMATIQUE D'UN INTERMEDIAIRE UTILISE POUR LA PREPARATION DE COMPOSES TRICYCLIQUES SUBSTITUES
Publication
Application
Priority
- US 9811501 W 19980615
- US 87767597 A 19970617
Abstract (en)
[origin: WO9858073A1] The invention relates to a process for preparing a substituted (6,11-dihydro-5H-benzo [5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of formula ((+)-I) wherein: R, R<1>, R<2>, R<3> and R<4> are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, amino, -OCH3, -OCF3 and CF3, and the dotted line represents an optional double bond; comprising: enzymatically catalyzing the acylation of a compound of the formula ((+/-)-II) wherein the variables are as defined above, and hydrolysing the product to obtain ((+)-I).
IPC 1-7
IPC 8 full level
C12P 17/12 (2006.01); C07D 401/04 (2006.01); C12P 17/16 (2006.01); C12P 41/00 (2006.01)
CPC (source: EP)
C12P 17/165 (2013.01); C12P 41/007 (2013.01)
Citation (search report)
See references of WO 9858073A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9858073 A1 19981223; AR 015892 A1 20010530; AU 8058398 A 19990104; CA 2293708 A1 19981223; CA 2293708 C 20040511; EP 1002123 A1 20000524; IN 187248 B 20020309; JP 2000512862 A 20001003; JP 3421355 B2 20030630; MY 133532 A 20071130; ZA 985217 B 19990107
DOCDB simple family (application)
US 9811501 W 19980615; AR P980102861 A 19980616; AU 8058398 A 19980615; CA 2293708 A 19980615; EP 98928889 A 19980615; IN 1292MA1998 A 19980615; JP 50449699 A 19980615; MY PI9802658 A 19980615; ZA 985217 A 19980615