EP 1003480 A1 20000531 - CONJUGATED PEPTIDE NUCLEIC ACIDS HAVING ENHANCED CELLULAR UPTAKE
Title (en)
CONJUGATED PEPTIDE NUCLEIC ACIDS HAVING ENHANCED CELLULAR UPTAKE
Title (de)
MIT PEPTIDEN KONJUGIERTE NUKLEINSÄUREN MIT ERHÖHTER AUFNAHME IN ZELLEN
Title (fr)
ACIDES NUCLEIQUES PEPTIDIQUES CONJUGUES PRESENTANT UNE FIXATION CELLULAIRE ACCRUE
Publication
Application
Priority
- US 9810804 W 19980528
- US 86476597 A 19970528
Abstract (en)
[origin: WO9853801A1] Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
IPC 1-7
A61K 9/127; A61K 31/70; A61K 38/00; C07H 21/00; C07K 1/00; C07K 1/13; C07K 2/00; C12N 5/00; C12Q 1/68
IPC 8 full level
C12N 15/09 (2006.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); C07H 21/00 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
A61K 9/1272 (2013.01); A61K 47/62 (2017.07); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); C07K 14/003 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9853801 A1 19981203; AU 745309 B2 20020321; AU 7602198 A 19981230; CA 2291839 A1 19981203; EP 1003480 A1 20000531; EP 1003480 A4 20020417; IL 133087 A0 20010319; JP 2001501975 A 20010213; NZ 501289 A 20010629
DOCDB simple family (application)
US 9810804 W 19980528; AU 7602198 A 19980528; CA 2291839 A 19980528; EP 98923819 A 19980528; IL 13308798 A 19980528; JP 50087199 A 19980528; NZ 50128998 A 19980528