EP 1003480 A4 20020417 - CONJUGATED PEPTIDE NUCLEIC ACIDS HAVING ENHANCED CELLULAR UPTAKE

Title (en)

CONJUGATED PEPTIDE NUCLEIC ACIDS HAVING ENHANCED CELLULAR UPTAKE

Title (de)

MIT PEPTIDEN KONJUGIERTE NUKLEINSÄUREN MIT ERHÖHTER AUFNAHME IN ZELLEN

Title (fr)

ACIDES NUCLEIQUES PEPTIDIQUES CONJUGUES PRESENTANT UNE FIXATION CELLULAIRE ACCRUE

Publication

EP 1003480 A4 20020417 (EN)

Application

EP 98923819 A 19980528

Priority

US 9810804 W 19980528
US 86476597 A 19970528

Abstract (en)

[origin: WO9853801A1] Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.

IPC 1-7

C07K 14/00; A61K 47/48; A61K 9/127; A61K 31/70; A61K 38/00; C07H 21/00; C07K 1/00; C07K 1/13; C07K 2/00; C12N 5/00; C12Q 1/68

IPC 8 full level

A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); C07H 21/00 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP)

A61K 9/1272 (2013.01); A61K 47/62 (2017.07); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); C07K 14/003 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

[XD] WO 9220702 A1 19921126 - BUCHARDT OLE [DK], et al
[XY] WO 9611205 A1 19960418 - ISIS PHARMACEUTICALS INC [US], et al
[A] WO 9619240 A1 19960627 - CIBA GEIGY AG [CH], et al
[A] WO 9604000 A1 19960215 - UNIV CALIFORNIA [US]
[Y] WITTUNG, P. ET AL.: "Phospholipid Membrane Permeability of Peptide Nucleic Acid", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 365, no. 1, 22 May 1995 (1995-05-22), pages 27 - 29, XP001056078
See references of WO 9853801A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9853801 A1 19981203; AU 745309 B2 20020321; AU 7602198 A 19981230; CA 2291839 A1 19981203; EP 1003480 A1 20000531; EP 1003480 A4 20020417; IL 133087 A0 20010319; JP 2001501975 A 20010213; NZ 501289 A 20010629

DOCDB simple family (application)

US 9810804 W 19980528; AU 7602198 A 19980528; CA 2291839 A 19980528; EP 98923819 A 19980528; IL 13308798 A 19980528; JP 50087199 A 19980528; NZ 50128998 A 19980528