EP 1003500 A1 20000531 - INTRAMURAL DELIVERY OF NITRIC OXIDE ENHANCER FOR INHIBITING LESION FORMATION AFTER VASCULAR INJURY
Title (en)
INTRAMURAL DELIVERY OF NITRIC OXIDE ENHANCER FOR INHIBITING LESION FORMATION AFTER VASCULAR INJURY
Title (de)
INTRAMURALE VERABREICHUNG VON STICKSTOFF MONOXID ZUR HEMMUNG DER LÄSIONSBILDUNG NACH EINER GEFÄSSVERLETZUNG
Title (fr)
APPORT INTRAMURAL D'UN ACTIVATEUR DE MONOXYDE D'AZOTE AFIN D'INHIBER LA FORMATION DE LESIONS APRES BLESSURE VASCULAIRE
Publication
Application
Priority
- US 9713905 W 19970807
- US 69579296 A 19960812
Abstract (en)
[origin: WO9806389A1] Vessels suffering vascular injury from angioplasty are treated with L-arginine intramurally. The incidents associated with restenosis are substantially reduced providing for reduced incidents of restenosis as a result of the injury. An iontophoretic catheter can be used for local delivery of the L-arginine. In the catheter, one electrode (28) is located within the catheter body (11) while the other electrode (31) is located on the body surface or within the body of the patient. The catheter balloon (26) is then inflated with the drug entering the balloon interior (27) through lumen (23). Activation of the power supply (30) causes the drug to cross the balloon wall (26) and contact the surrounding vessel wall (15) and vascular tissue.
IPC 1-7
IPC 8 full level
A23L 1/305 (2006.01); A61K 31/198 (2006.01); A61K 38/04 (2006.01); A61K 38/16 (2006.01); A61K 38/44 (2006.01); A61M 25/00 (2006.01); A61P 9/14 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A23L 33/175 (2016.07); A61K 31/198 (2013.01); A61P 9/14 (2017.12); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9806389 A1 19980219; DE 69637676 D1 20081023; EP 1003500 A1 20000531; EP 1003500 A4 20040623; JP 2000516612 A 20001212
DOCDB simple family (application)
US 9713905 W 19970807; DE 69637676 T 19961024; EP 97938163 A 19970807; JP 50986098 A 19970807