EP 1003500 A4 20040623 - INTRAMURAL DELIVERY OF NITRIC OXIDE ENHANCER FOR INHIBITING LESION FORMATION AFTER VASCULAR INJURY

Title (en)

INTRAMURAL DELIVERY OF NITRIC OXIDE ENHANCER FOR INHIBITING LESION FORMATION AFTER VASCULAR INJURY

Title (de)

INTRAMURALE VERABREICHUNG VON STICKSTOFF MONOXID ZUR HEMMUNG DER LÄSIONSBILDUNG NACH EINER GEFÄSSVERLETZUNG

Title (fr)

APPORT INTRAMURAL D'UN ACTIVATEUR DE MONOXYDE D'AZOTE AFIN D'INHIBER LA FORMATION DE LESIONS APRES BLESSURE VASCULAIRE

Publication

EP 1003500 A4 20040623 (EN)

Application

EP 97938163 A 19970807

Priority

US 9713905 W 19970807
US 69579296 A 19960812

Abstract (en)

[origin: WO9806389A1] Vessels suffering vascular injury from angioplasty are treated with L-arginine intramurally. The incidents associated with restenosis are substantially reduced providing for reduced incidents of restenosis as a result of the injury. An iontophoretic catheter can be used for local delivery of the L-arginine. In the catheter, one electrode (28) is located within the catheter body (11) while the other electrode (31) is located on the body surface or within the body of the patient. The catheter balloon (26) is then inflated with the drug entering the balloon interior (27) through lumen (23). Activation of the power supply (30) causes the drug to cross the balloon wall (26) and contact the surrounding vessel wall (15) and vascular tissue.

IPC 1-7

A61K 31/195; A61M 25/10; A61M 29/02; A61N 1/30

IPC 8 full level

A61M 25/00 (2006.01); A23L 1/305 (2006.01); A61K 31/198 (2006.01); A61K 38/04 (2006.01); A61K 38/16 (2006.01); A61K 38/44 (2006.01); A61P 9/14 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP)

A23L 33/175 (2016.07); A61K 31/198 (2013.01); A61P 9/14 (2017.12); A61K 48/00 (2013.01)

Citation (search report)

[PX] WO 9716983 A1 19970515 - UNIV LELAND STANFORD JUNIOR [US]
[X] WO 9524898 A1 19950921 - COMEDICUS INC [US]
[X] US 5171217 A 19921215 - MARCH KEITH L [US], et al
[A] WO 9505866 A1 19950302 - CORTRAK MEDICAL INC [US]
[A] WO 9600112 A1 19960104 - CORMEDICS CORP [US], et al
[A] EP 0483614 A1 19920506 - NB INT TECH [CH]
See references of WO 9806389A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9806389 A1 19980219; DE 69637676 D1 20081023; EP 1003500 A1 20000531; EP 1003500 A4 20040623; JP 2000516612 A 20001212

DOCDB simple family (application)

US 9713905 W 19970807; DE 69637676 T 19961024; EP 97938163 A 19970807; JP 50986098 A 19970807