Global Patent Index - EP 1003511 A1

EP 1003511 A1 2000-05-31 - ALPHA 1aADRENERGIC RECEPTOR ANTAGONISTS

Title (en)

ALPHA 1aADRENERGIC RECEPTOR ANTAGONISTS

Title (de)

ANTAGONISTEN DES ALPHA 1a REZEPTORS

Title (fr)

ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a

Publication

EP 1003511 A1 (EN)

Application

EP 98930349 A

Priority

  • GB 9800456 A
  • US 9812659 W
  • US 5013797 P

Abstract (en)

[origin: WO9857639A1] This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha la adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

IPC 1-7 (main, further and additional classification)

A61K 31/445; A61K 31/505; C07D 211/18; C07D 239/34; C07D 401/12; C07D 411/12; C07D 413/12; C07D 487/04; C07D 491/08

IPC 8 full level (invention and additional information)

A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/506 (2006.01); A61P 13/02 (2006.01); A61P 13/08 (2006.01); A61P 43/00 (2006.01); C07D 205/04 (2006.01); C07D 207/09 (2006.01); C07D 207/14 (2006.01); C07D 211/26 (2006.01); C07D 211/56 (2006.01); C07D 239/22 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 487/04 (2006.01); C07D 491/04 (2006.01)

CPC (invention and additional information)

C07D 239/22 (2013.01); C07D 205/04 (2013.01); C07D 211/56 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 413/06 (2013.01); C07D 417/06 (2013.01); C07D 487/04 (2013.01); C07D 491/04 (2013.01)

Citation (search report)

See references of WO 9857639A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9857639 A1 19981223; AU 7975998 A 19990104; CA 2294349 A1 19981223; EP 1003511 A1 20000531; JP 2002504931 A 20020212

INPADOC legal status


2001-07-18 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20010101

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000118

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE